Padres vs Rays Prediction, Odds, Moneyline, Spread & Over/Under for April 26

Odds updated as of 9:11 a.m.

On Saturday in MLB, the San Diego Padres are up against the Tampa Bay Rays.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important information regarding this matchup.

Padres vs Rays Game Info

• San Diego Padres (17-9) vs. Tampa Bay Rays (12-14)
• Date: Saturday, April 26, 2025
• Time: 8:40 p.m. ET
• Venue: PETCO Park -- San Diego, California
• Coverage: SDPA and FDSSUN

Padres vs Rays Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-154) | TB: (+130)
• Spread: SD: -1.5 (+136) | TB: +1.5 (-164)
• Total: 7 -- Over: (-122) | Under: (-100)

Padres vs Rays Probable Starting Pitchers

Probable Pitchers: Dylan Edward Cease (Padres) - 1-1, 6.04 ERA vs Ryan Pepiot (Rays) - 1-3, 4.82 ERA

The Padres will give the nod to Dylan Edward Cease (1-1, 6.04 ERA), who is eyeing win No. 2 on the season, and the Rays will turn to Ryan Pepiot (1-3, 4.82 ERA). Cease and his team are 2-3-0 ATS this season when he starts. Cease's team has been victorious in 75% of the games he's started as the moneyline favorite with a record of 3-1. The Rays did not cover any of Pepiot's five starts with a set spread. The Rays were the moneyline underdog for two Pepiot starts this season -- they lost both.

Padres vs Rays Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (56.6%)

Padres vs Rays Moneyline

• San Diego is the favorite, -154 on the moneyline, while Tampa Bay is a +130 underdog on the road.

Padres vs Rays Spread

• The Padres are hosting the Rays and are favored by 1.5 runs (+136 to cover) on the runline. Tampa Bay is -164 to cover.

Padres vs Rays Over/Under

• The over/under for Padres-Rays on April 26 is 7. The over is -122, and the under is -100.

Bet on San Diego Padres vs. Tampa Bay Rays on FanDuel today!

Padres vs Rays Betting Trends

• The Padres have been favorites in 13 games this season and have come away with the win 10 times (76.9%) in those contests.
• San Diego has been a -154 moneyline favorite on six occasions this season and won every time.
• The Padres and their opponents have hit the over in 10 of their 26 games with a total set by oddsmakers this season.
• The Padres have an against the spread record of 15-11-0 in 26 games with a line this season.
• The Rays have a 4-6 record in games they were the underdog on the moneyline (winning 40% of those games).
• In games it has played as a moneyline underdog with odds of +130 or longer, Tampa Bay has a 2-3 record (winning 40% of its games).
• The Rays have had an over/under set by bookmakers 26 times, and have combined with opponents to go over the total in 11 of those games (11-13-2).
• The Rays have put together an 11-15-0 record ATS this season (covering 42.3% of the time).

Padres Player Leaders

• Fernando Tatis Jr. has 33 hits and an OBP of .409 to go with a slugging percentage of .629. All three of those stats lead San Diego hitters this season. He has a .340 batting average, as well.
• Among qualifying hitters in the majors, he ranks fifth in batting average, 10th in on-base percentage, and fourth in slugging.
• Manny Machado is batting .281 with nine doubles, two home runs and 10 walks. He's slugging .438 with an on-base percentage of .349.
• Among qualified hitters, his batting average ranks him 44th, his on-base percentage 52nd, and his slugging percentage 57th.
• Xander Bogaerts has 22 hits this season and has a slash line of .250/.343/.341.
• Gavin Sheets has three home runs, 12 RBI and a batting average of .292 this season.

Rays Player Leaders

• Jonathan Aranda has accumulated 23 hits with a .409 on-base percentage, leading the Rays in both categories. He's batting .311 and slugging .581.
• Including all the qualified hitters in the majors, his batting average is 15th, his on-base percentage ranks 10th, and he is ninth in slugging.
• Yandy (Fernandez) Diaz's .398 slugging percentage paces his team. He has a batting average of .250 with an on-base percentage of .284.
• He is currently 76th in batting average, 119th in on-base percentage and 84th in slugging percentage among all qualifying batters.
• Kameron Misner is hitting .328 with seven doubles, a triple, three home runs and five walks.
• Junior Caminero is hitting .250 with four doubles, five home runs and six walks.

Padres vs Rays Head to Head

• 4/25/2025: 1-0 TB (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 9/1/2024: 4-3 SD (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 8/31/2024: 11-4 TB (Favorite: Rays, Spread: -1.5, Total: 8, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 8/30/2024: 13-5 SD (Favorite: Rays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/18/2023: 5-4 SD (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 6/17/2023: 2-0 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/16/2023: 6-2 TB (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!