Padres vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 3

Odds updated as of 12:13 a.m.

The MLB schedule on Sunday includes the San Diego Padres taking on the St. Louis Cardinals.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Padres vs Cardinals Game Info

• San Diego Padres (61-49) vs. St. Louis Cardinals (55-56)
• Date: Sunday, August 3, 2025
• Time: 4:10 p.m. ET
• Venue: PETCO Park -- San Diego, California
• Coverage: SDPA and FDSMW

Padres vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-146) | STL: (+124)
• Spread: SD: -1.5 (+142) | STL: +1.5 (-172)
• Total: 8.5 -- Over: (-118) | Under: (-104)

Padres vs Cardinals Probable Starting Pitchers

Probable Pitchers: Dylan Cease (Padres) - 3-10, 4.79 ERA vs Andre Pallante (Cardinals) - 6-7, 4.62 ERA

The Padres will give the nod to Dylan Cease (3-10, 4.79 ERA), who is eyeing win No. 4 on the season, and the Cardinals will counter with Andre Pallante (6-7, 4.62 ERA). Cease and his team are 9-13-0 ATS this season when he starts. Cease's team has been victorious in 60% of the games he's started as the moneyline favorite with a record of 9-6. The Cardinals have gone 12-9-0 against the spread when Pallante starts. The Cardinals are 6-6 in Pallante's 12 starts this season that they were the moneyline underdog.

Padres vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (58.6%)

Padres vs Cardinals Moneyline

• San Diego is a -146 favorite on the moneyline, while St. Louis is a +124 underdog on the road.

Padres vs Cardinals Spread

• The Padres are favored by 1.5 runs at home versus the Cardinals. The Padres are +142 to cover the spread, while the Cardinals are -172.

Padres vs Cardinals Over/Under

• The Padres-Cardinals contest on Aug. 3 has been given an over/under of 8.5 runs. The over is set at -118 and the under at -104.

Bet on San Diego Padres vs. St. Louis Cardinals on FanDuel today!

Padres vs Cardinals Betting Trends

• The Padres have been chosen as favorites in 54 games this year and have walked away with the win 33 times (61.1%) in those games.
• This season San Diego has been victorious 19 times in 29 chances when named as a favorite of at least -146 on the moneyline.
• Contests with the Padres have gone over the total set by sportsbooks in 44 of 108 chances this season.
• The Padres have posted a record of 60-48-0 against the spread this season.
• The Cardinals have gone 27-28 in games they were the underdog on the moneyline (winning 49.1% of those games).
• St. Louis has gone 7-12 in games it has played as a moneyline underdog with odds of +124 or longer (36.8%).
• In the 108 games oddsmakers have set an over/under for the Cardinals, they have combined with opponents to go over the total 54 times (54-49-5).
• The Cardinals have a 56-52-0 record against the spread this season (covering 51.9% of the time).

Padres Player Leaders

• Manny Machado leads San Diego with 128 hits and a team-best slugging percentage of .507. He's batting .302 with an on-base percentage of .361.
• Among the qualifying hitters in baseball, his batting average ranks eighth, his on-base percentage ranks 29th, and he is 16th in slugging.
• Machado hopes to build on a nine-game hitting streak in this matchup. In his last 10 outings he is hitting .452 with four doubles, two home runs and 11 RBIs.
• Fernando Tatis Jr. is batting .267 with 18 doubles, two triples, 17 home runs and 61 walks, while slugging .446 with an on-base percentage of .368.
• Among qualifying hitters, his batting average places him 62nd, his on-base percentage 22nd, and his slugging percentage 68th.
• Luis Arraez is batting .297 with a .406 slugging percentage and 41 RBI this year.
• Arraez has picked up a hit in 14 straight games. In his last 10 games he is batting .425 with three doubles, a home run, three walks and five RBIs.
• Xander Bogaerts is batting .267 with a .339 OBP and 37 RBI for San Diego this season.
• Bogaerts takes a two-game hitting streak into this matchup. In his last five games he is hitting .273 with a double, a home run, a walk and two RBIs.

Cardinals Player Leaders

• Brendan Donovan has racked up an on-base percentage of .354 and a slugging percentage of .412. Both lead the Cardinals. He's batting .282.
• He is 28th in batting average, 39th in on-base percentage and 94th in slugging percentage among all qualifying hitters in the big leagues.
• Alec Burleson paces his team with 96 hits. He has a batting average of .284 while slugging .464 with an on-base percentage of .338.
• He is currently 26th in batting average, 63rd in on-base percentage and 49th in slugging percentage among all qualified hitters.
• Willson Contreras is batting .257 with 28 doubles, 15 home runs and 34 walks.
• Masyn Winn is hitting .271 with 23 doubles, seven home runs and 27 walks.

Padres vs Cardinals Head to Head

• 8/1/2025: 4-1 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -205, Underdog Moneyline: +172)
• 7/27/2025: 9-2 SD (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 7/26/2025: 3-1 SD (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/25/2025: 3-0 STL (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/24/2025: 9-7 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 8/29/2024: 4-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 8/28/2024: 4-3 STL (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 8/27/2024: 7-5 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 8/26/2024: 7-4 SD (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 4/3/2024: 3-2 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -158, Underdog Moneyline: +134)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!