Padres vs Brewers Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 22

Odds updated as of 6:12 a.m.

Monday's slate in the MLB includes a matchup between the San Diego Padres and the Milwaukee Brewers.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Padres vs Brewers Game Info

• San Diego Padres (85-71) vs. Milwaukee Brewers (95-61)
• Date: Monday, September 22, 2025
• Time: 9:40 p.m. ET
• Venue: PETCO Park -- San Diego, California
• Coverage: SDPA and FDSWI

Padres vs Brewers Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-130) | MIL: (+110)
• Spread: SD: -1.5 (+168) | MIL: +1.5 (-205)
• Total: 7 -- Over: (-118) | Under: (-104)

Padres vs Brewers Probable Starting Pitchers

Probable Pitchers: Nick Pivetta (Padres) - 13-5, 2.81 ERA vs Freddy Peralta (Brewers) - 17-6, 2.65 ERA

The probable pitchers are Nick Pivetta (13-5) for the Padres and Freddy Peralta (17-6) for the Brewers. Pivetta's team is 17-13-0 against the spread this season in his starts. Pivetta's team has a record of 11-8 this season when he starts and they are the favorite on the moneyline. The Brewers are 18-13-0 ATS in Peralta's 31 starts with a set spread. The Brewers have been the underdog on the moneyline in 11 of Peralta's starts this season, and they went 6-5 in those matchups.

Padres vs Brewers Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (52.1%)

Padres vs Brewers Moneyline

• Looking at the moneyline for Brewers-Padres, Milwaukee is the underdog at +110, and San Diego is -130 playing at home.

Padres vs Brewers Spread

• The Brewers are at the Padres, and are +1.5 on the runline. The Brewers are +168 to cover the spread, and the Padres are -205.

Padres vs Brewers Over/Under

• Padres versus Brewers, on Sept. 22, has an over/under of 7, with the over being -118 and the under -104.

Bet on San Diego Padres vs. Milwaukee Brewers on FanDuel today!

Padres vs Brewers Betting Trends

• The Padres have been favorites in 85 games this season and have come away with the win 51 times (60%) in those contests.
• This season San Diego has been victorious 46 times in 75 chances when named as a favorite of at least -130 on the moneyline.
• The Padres and their opponents have hit the over in 67 of their 154 games with a total set by oddsmakers this season.
• The Padres have posted a record of 82-72-0 against the spread this season.
• The Brewers have been the moneyline underdog 59 total times this season. They've gone 33-26 in those games.
• When playing as a moneyline underdog with odds of +110 or longer, Milwaukee has gone 18-17 (51.4%).
• In the 153 games oddsmakers have set an over/under for the Brewers, they have combined with opponents to go over the total 77 times (77-74-2).
• The Brewers are 85-68-0 against the spread this season.

Padres Player Leaders

• Fernando Tatis Jr. is hitting .267 with 27 doubles, two triples, 23 home runs and 88 walks. He has an on-base percentage of .367 and a slugging percentage of .438.
• Among qualified batters, he is 44th in batting average, his on-base percentage ranks 13th, and he is 66th in slugging.
• Tatis will look for his sixth straight game with a hit in this contest. In his last five games he is batting .381 with a home run, two walks and an RBI.
• Manny Machado has 33 doubles, 26 home runs and 53 walks. He's batting .275 and slugging .459 with an on-base percentage of .334.
• He ranks 33rd in batting average, 66th in on-base percentage and 49th in slugging among qualified hitters.
• Luis Arraez leads San Diego in slugging percentage (.383) powered by 40 extra-base hits.
• Arraez brings a 10-game hitting streak into this game. During his last 10 outings he is batting .350 with two walks and four RBIs.
• Ramon Laureano has 123 hits, which is tops among San Diego hitters this season, while batting .282 with 52 extra-base hits.

Brewers Player Leaders

• William Contreras has accumulated a team-high .360 on-base percentage. He's batting .265 and slugging .407.
• Including all the qualifying hitters in the big leagues, he ranks 52nd in batting average, 18th in on-base percentage and 92nd in slugging percentage.
• Brice Turang leads his team with a .435 slugging percentage. He has a batting average of .286 with an on-base percentage of .355.
• He is currently 17th in batting average, 30th in on-base percentage and 71st in slugging percentage among all qualifying hitters.
• Christian Yelich is hitting .266 with 20 doubles, 29 home runs and 60 walks.
• Jackson Chourio leads his team with 144 hits.

Padres vs Brewers Head to Head

• 6/8/2025: 1-0 SD (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 6/7/2025: 4-3 MIL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 6/6/2025: 2-0 SD (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 6/23/2024: 6-2 MIL (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 6/22/2024: 6-4 SD (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 6/21/2024: 9-5 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 6/20/2024: 7-6 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 4/17/2024: 1-0 MIL (Favorite: Brewers, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/16/2024: 6-3 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 4/15/2024: 7-3 SD (Favorite: Brewers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)

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