Orioles vs Nationals Prediction, Odds, Moneyline, Spread & Over/Under for May 16

Odds updated as of 6:11 a.m.

The MLB's Friday slate includes the Baltimore Orioles facing the Washington Nationals.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Orioles vs Nationals Game Info

• Baltimore Orioles (15-27) vs. Washington Nationals (18-27)
• Date: Friday, May 16, 2025
• Time: 7:05 p.m. ET
• Venue: Oriole Park at Camden Yards -- Baltimore, Maryland
• Coverage: MASN and MASN2

Orioles vs Nationals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BAL: (-110) | WSH: (-106)
• Spread: BAL: +1.5 (-200) | WSH: -1.5 (+164)
• Total: 9 -- Over: (-110) | Under: (-110)

Orioles vs Nationals Probable Starting Pitchers

Probable Pitchers: Cade Povich (Orioles) - 1-3, 5.55 ERA vs MacKenzie Gore (Nationals) - 2-4, 3.59 ERA

The Orioles will give the ball to Cade Povich (1-3, 5.55 ERA), who is eyeing win No. 2 on the season, and the Nationals will counter with MacKenzie Gore (2-4, 3.59 ERA). Povich and his team have a record of 1-6-0 against the spread when he starts. When Povich starts a game and his team is the favorite on the moneyline, they have a record of 2-2. When Gore starts, the Nationals are 4-5-0 against the spread. The Nationals have a 1-2 record in Gore's three starts this season when they were the moneyline underdog.

Orioles vs Nationals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Orioles win (52.4%)

Orioles vs Nationals Moneyline

• Baltimore is a -110 favorite on the moneyline, while Washington is a -106 underdog on the road.

Orioles vs Nationals Spread

• The Nationals are 1.5-run favorites against the spread for this matchup with the Orioles. The Nationals are +164 to cover, while the Orioles are -200 to cover as a 1.5-run underdog on the runline.

Orioles vs Nationals Over/Under

• Orioles versus Nationals, on May 16, has an over/under of 9, with the over being -110 and the under -110.

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Orioles vs Nationals Betting Trends

• The Orioles have been chosen as favorites in 24 games this year and have walked away with the win nine times (37.5%) in those games.
• This season Baltimore has come away with a win nine times in 24 chances when named as a favorite of at least -110 on the moneyline.
• Contests with the Orioles have gone over the total set by sportsbooks in 20 of 42 chances this season.
• The Orioles have an against the spread mark of 13-29-0 in 42 games with a line this season.
• The Nationals have been the moneyline underdog 33 total times this season. They've finished 15-18 in those games.
• In games it has played as a moneyline underdog with odds of -106 or longer, Washington has a record of 15-18 (45.5%).
• The Nationals have played in 43 games with a set over/under, and have combined with their opponents to go over the total 21 times (21-21-1).
• The Nationals have a 22-21-0 record ATS this season (covering 51.2% of the time).

Orioles Player Leaders

• Cedric Mullins leads Baltimore with an OBP of .335 this season while batting .232 with 20 walks and 21 runs scored. He has a slugging percentage of .451.
• Among all qualifying hitters in baseball, he ranks 116th in batting average, 74th in on-base percentage, and 60th in slugging.
• Mullins will look for his third straight game with a hit in this matchup. During his last five outings he is hitting .263 with two doubles, a home run and four RBIs.
• Ryan O'Hearn has four doubles, seven home runs and 13 walks. He's batting .295 and slugging .518 with an on-base percentage of .378.
• O'Hearn heads into this game looking to extend his two-game hit streak. During his last five outings he is hitting .235 with three walks.
• Gunnar Henderson has a team-high 38 hits to go with a slugging percentage of .479.
• Adley Rutschman is batting .200 with a .300 OBP and 11 RBI for Baltimore this season.

Nationals Player Leaders

• James Wood has a .523 slugging percentage, which leads the Nationals. He's batting .267 with an on-base percentage of .364.
• He ranks 61st in batting average, 40th in on-base percentage and 20th in slugging percentage among all qualifying hitters in the majors.
• C.J. Abrams leads his team with 40 hits and a .379 OBP. He has a batting average of .317 while slugging .548.
• His batting average ranks ninth among all qualified players, his on-base percentage ranks 26th, and he is 13th in slugging.
• Nathaniel Lowe is hitting .226 with seven doubles, seven home runs and 18 walks.
• Keibert Ruiz has six doubles, two home runs and eight walks while hitting .285.

Orioles vs Nationals Head to Head

• 4/24/2025: 2-1 BAL (Favorite: Nationals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 4/23/2025: 4-3 WSH (Favorite: Orioles, Spread: -1.5, Total: 9.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 4/22/2025: 7-0 WSH (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 8/14/2024: 4-1 BAL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 8/13/2024: 9-3 WSH (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 5/8/2024: 7-6 BAL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 5/7/2024: 3-0 WSH (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -215, Underdog Moneyline: +180)
• 9/27/2023: 5-1 BAL (Favorite: Orioles, Spread: -1.5, Total: 7.5, Favorite Moneyline: -255, Underdog Moneyline: +210)
• 9/26/2023: 1-0 BAL (Favorite: Orioles, Spread: -1.5, Total: 7.5, Favorite Moneyline: -250, Underdog Moneyline: +205)
• 4/19/2023: 4-0 BAL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)

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