Giants vs Athletics Prediction, Odds, Moneyline, Spread & Over/Under for May 16

Odds updated as of 8:11 a.m.

Friday's slate in the MLB includes a matchup between the San Francisco Giants and the Athletics.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Giants vs Athletics Game Info

• San Francisco Giants (25-19) vs. Athletics (22-22)
• Date: Friday, May 16, 2025
• Time: 10:15 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: MLB Network, NBCS-BA, and NBCS-CA

Giants vs Athletics Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SF: (-172) | OAK: (+144)
• Spread: SF: -1.5 (+126) | OAK: +1.5 (-152)
• Total: 7 -- Over: (-122) | Under: (-100)

Giants vs Athletics Probable Starting Pitchers

Probable Pitchers: Logan Webb (Giants) - 4-3, 2.60 ERA vs JP Sears (Athletics) - 4-2, 2.80 ERA

The Giants will give the nod to Logan Webb (4-3) versus the Athletics and JP Sears (4-2). Webb and his team have a record of 5-4-0 against the spread when he starts. Webb's team has been victorious in 50% of the games he's started as the moneyline favorite with a record of 4-4. When Sears starts, the Athletics are 6-2-0 against the spread. The Athletics have been the underdog on the moneyline in three of Sears' starts this season, and they went 1-2 in those matchups.

Giants vs Athletics Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Giants win (64.2%)

Giants vs Athletics Moneyline

• The Giants vs Athletics moneyline has the Giants as a -172 favorite, while the Athletics are a +144 underdog on the road.

Giants vs Athletics Spread

• The Giants are 1.5-run favorites on the runline against the Athletics. The Giants are +126 to cover, while the Athletics are -152 to cover.

Giants vs Athletics Over/Under

• The over/under for Giants-Athletics on May 16 is 7. The over is -122, and the under is -100.

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Giants vs Athletics Betting Trends

• The Giants have won in 16, or 61.5%, of the 26 contests they have been named as odds-on favorites in this year.
• This season, the Giants have come away with a win three times in four chances when named as a favorite of at least -172 or shorter on the moneyline.
• The Giants and their opponents have hit the over in 25 of their 44 games with a total this season.
• In 44 games with a line this season, the Giants have a mark of 23-21-0 against the spread.
• The Athletics have won 39.3% of the games this season they were the moneyline underdog (11-17).
• The Athletics have a record of 1-5 in games they have played as a moneyline underdog with odds of +144 or longer (16.7%).
• The Athletics have combined with their opponents to hit the over on the total 24 times this season for a 24-17-3 record against the over/under.
• The Athletics have covered 50% of their games this season, going 22-22-0 ATS.

Giants Player Leaders

• Jung Hoo Lee leads San Francisco in slugging percentage (.482) thanks to 19 extra-base hits. He has a .286 batting average and an on-base percentage of .330.
• Among qualifying hitters, he ranks 38th in batting average, his on-base percentage ranks 83rd, and he is 38th in slugging.
• Lee will look for his fifth straight game with a hit in this contest. During his last five outings he is hitting .238 with two home runs and six RBIs.
• Heliot Ramos leads San Francisco with 47 hits. He is batting .288 this season and has 18 extra-base hits. He's also slugging .485 with an on-base percentage of .353.
• His batting average is 37th among qualified players, his on-base percentage 52nd, and his slugging percentage 36th.
• Matt Chapman has collected 34 base hits, an OBP of .349 and a slugging percentage of .413 this season.
• Wilmer Flores has seven home runs, 33 RBI and a batting average of .255 this season.
• Flores has safely hit in three games in a row. In his last five games he is hitting .294 with two walks.

Athletics Player Leaders

• Jacob Wilson has racked up a team-best OBP (.377) and slugging percentage (.491). He's batting .347.
• Including all qualifying players in MLB, he is third in batting average, 28th in on-base percentage and 31st in slugging percentage.
• Tyler Soderstrom paces his team with 47 hits. He has a batting average of .280 while slugging .506 with an on-base percentage of .341.
• His batting average ranks 46th among all qualified players, his on-base percentage ranks 67th, and he is 26th in slugging.
• Shea Langeliers is batting .266 with six doubles, eight home runs and 14 walks.
• Brent Rooker is batting .249 with seven doubles, a triple, 10 home runs and 14 walks.

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