Orioles vs Astros Prediction, Odds, Moneyline, Spread & Over/Under for April 28

Odds updated as of 6:12 p.m.

In MLB action on Tuesday, the Baltimore Orioles play the Houston Astros.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Orioles vs Astros Game Info

• Baltimore Orioles (13-15) vs. Houston Astros (11-18)
• Date: Tuesday, April 28, 2026
• Time: 6:35 p.m. ET
• Venue: Oriole Park at Camden Yards -- Baltimore, Maryland
• Coverage: MASN and SCHN

Orioles vs Astros Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BAL: (-136) | HOU: (+116)
• Spread: BAL: -1.5 (+136) | HOU: +1.5 (-164)
• Total: 9 -- Over: (-115) | Under: (-105)

Orioles vs Astros Probable Starting Pitchers

Probable Pitchers: Shane Baz (Orioles) - 0-2, 5.08 ERA vs Kai-Wei Teng (Astros) - 1-1, 2.16 ERA

The Orioles will call on Shane Baz (0-2) against the Astros and Kai-Wei Teng (1-1). Baz's team is 2-3-0 against the spread this season in his starts. Baz's team is 1-1 this season when he starts and they're favored on the moneyline. Last season Teng and his team finished 2-5-0 against the spread in games he pitched. Teng and his team lost all six games he appeared in when they were the moneyline underdog a season ago.

Orioles vs Astros Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (54.9%)

Orioles vs Astros Moneyline

• Houston is the underdog, +116 on the moneyline, while Baltimore is a -136 favorite at home.

Orioles vs Astros Spread

• The Astros are at the Orioles, and are +1.5 on the runline. The Astros are +136 to cover the spread, and the Orioles are -164.

Orioles vs Astros Over/Under

• The over/under for the Orioles versus Astros contest on April 28 has been set at 9, with -115 odds on the over and -105 odds on the under.

Bet on Baltimore Orioles vs. Houston Astros on FanDuel today!

Orioles vs Astros Betting Trends

• The Orioles have been chosen as favorites in 18 games this year and have walked away with the win 10 times (55.6%) in those games.
• This year Baltimore has won five of nine games when listed as at least -136 on the moneyline.
• The Orioles and their opponents have hit the over in 18 of their 28 games with a total set by oddsmakers this season.
• The Orioles have an against the spread record of 12-16-0 in 28 games with a line this season.
• The Astros have won 41.7% of the games this season they were the moneyline underdog (5-7).
• Houston is 2-6 (winning only 25% of its games) when it has played as a moneyline underdog of +116 or longer.
• The Astros have had an over/under set by oddsmakers 29 times, and have combined with opponents to go over the total in 21 of those games (21-8-0).
• The Astros have covered only 37.9% of their games this season, going 11-18-0 ATS.

Orioles Player Leaders

• Taylor Ward leads Baltimore with an OBP of .424, plus a team-best slugging percentage of .459. He's batting .312 on the season.
• Among qualified hitters, he is 15th in batting average, his on-base percentage ranks fourth, and he is 55th in slugging.
• Gunnar Henderson leads Baltimore in total hits (25) this season while batting .210 with 14 extra-base hits. He's slugging .487 with an on-base percentage of .280.
• He ranks 146th in batting average, 157th in on-base percentage and 36th in slugging among qualified batters.
• Jeremiah Jackson has 24 hits this season and has a slash line of .270/.290/.461.
• Leody Taveras is batting .288 with a .400 OBP and 15 RBI for Baltimore this season.

Astros Player Leaders

• Yordan Alvarez has accumulated a team-best OBP (.465) and slugging percentage (.755), and paces the Astros in hits (38, while batting .358).
• Including all qualified hitters in the majors, his batting average puts him first, his on-base percentage is first, and he is first in slugging.
• Alvarez enters this game on a 12-game hitting streak. In his last 10 games he is hitting .395 with three doubles, four home runs, two walks and nine RBIs.
• Christian Walker is hitting .291 with eight doubles, seven home runs and 13 walks. He's slugging .573 with an on-base percentage of .373.
• Including all qualified hitters, his batting average places him 31st, his on-base percentage is 31st, and he is eighth in slugging.
• Carlos Correa is batting .281 with seven doubles, two home runs and 15 walks.
• Jose Altuve is batting .260 with seven doubles, three home runs and 16 walks.

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