North Texas vs Indiana Prediction, Picks, NCAA Football Odds & Best Bets Today

College Football Betting Picks in Summary

• Indiana -40.5
• Over 55.5
• Indiana Over 517.5 Total Yards

North Texas travels to Indiana Saturday afternoon in one of the widest spreads on the entire college football board — a 40.5-point line with no moneyline even posted, a real sign of just how lopsided the market considers this one.

All college football odds come from FanDuel Sportsbook's college football betting odds and may change after this article is published.

College Football Predictions and Picks

North Texas at Indiana (Sat, 12:00 p.m. ET)

Indiana -40.5 (-110)

Ranked No. 6 nationally and favored by more than 40 points at home, Indiana's own first-half spread alone sits at -23.5 — a real sign the Hoosiers are expected to have this decided well before halftime.

Over 55.5 (-114)

Indiana's own projected yardage output (517.5) is more than enough on its own to threaten this total, regardless of how much North Texas is able to produce on the other side.

Indiana Over 517.5 Total Yards (-114)

Indiana's rushing attack alone is projected at 239.5 yards, meaning the passing game only needs to add another 278 or so to clear this number — a genuinely reasonable ask for a No. 6 team against this level of competition.