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FanDuel Research>
NFL>
Matchups>
San Francisco 49ers Vs. Indianapolis Colts

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Popular Bets

Odds not available yet.

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4 Leg Parlay

+2000

Player

Any Time Touchdown Scorer

Player 40+ Yards

Player - Alt Rushing Yds

Player 250+ Yards

Player - Alt Passing Yds

Player 5+ Receptions

Player - Alt Receptions

1425 People Placed

4 Leg Parlay

+2000

Player

Any Time Touchdown Scorer

Player 40+ Yards

Player - Alt Rushing Yds

Player 250+ Yards

Player - Alt Passing Yds

Player 5+ Receptions

Player - Alt Receptions

1425 People Placed

Odds not available yet.

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Type

Passing Yards

Receiving Yards

Rushing Yards

Passing Touchdowns

Player

QB • 100 Average Yards

Player

QB • 100 Average Yards

Player

QB • 100 Average Yards

Player

QB • 100 Average Yards

Game Log

Line Movement

These graphs show how the spread, moneyline, and total have shifted at FanDuel Sportsbook over time.

Spread

49ers

Open: -

Colts

Open: -

Odds not available yet.

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Moneyline

49ers

Open: -

Colts

Open: -

Odds not available yet.

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Total

Over

Open: -

Under

Open: -

Odds not available yet.

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ESPN

San Francisco 49ers

9-4 | 3rd in NFC West | 7th in NFC

SpreadMoneylineTotal

@

Indianapolis Colts

8-4 | 2nd in AFC South | 6th in AFC

SpreadMoneylineTotal

ESPN

Lucas Oil Stadium

San Francisco 49ers

18.1 Points

RBChristian McCaffrey

17.4 Points

WRBrandon Aiyuk

10.1 Points

TEGeorge Kittle

9.1 Points

Indianapolis Colts

RBJonathan Taylor

20.6 Points

19.3 Points

13.3 Points

10.0 Points

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NFL

3 Best NFL Player Prop Bets for Week 13

3 Best NFL Player Prop Bets for Week 13

Jim Sannes

• 1d

Cam Ward has started to use his legs a bit more recently. Could that lead to value in his prop markets as the Titans host the Jaguars in Week 13?

3 Best NFL Touchdown Prop Bets for Week 13

Jim Sannes

• 1d

3 Best NFL Touchdown Prop Bets for Week 13

4 Best NFL Bets and Predictions for Week 13

Jim Sannes

• 4d

4 Best NFL Bets and Predictions for Week 13

FanDuel NFL DFS Picks for Week 13

Austan Kas

• 3d

FanDuel NFL DFS Picks for Week 13

NFL Week 13 Spread and Total Predictions for Every Game

Jim Sannes

• 6d

NFL Week 13 Spread and Total Predictions for Every Game

2 Best NFL Touchdown Prop Bets for Thanksgiving Day

Jim Sannes

• 5d

2 Best NFL Touchdown Prop Bets for Thanksgiving Day

3 Best NFL Player Prop Bets for Thanksgiving

Jim Sannes

• 5d

3 Best NFL Player Prop Bets for Thanksgiving

3 Best NFL Bets and Player Props for Chiefs at Cowboys on Thanksgiving

Jim Sannes

• 5d

3 Best NFL Bets and Player Props for Chiefs at Cowboys on Thanksgiving

2 Best NFL Bets and Player Props for Packers at Lions on Thanksgiving

Austan Kas

• 5d

2 Best NFL Bets and Player Props for Packers at Lions on Thanksgiving

2 Best NFL Bets and Player Props for Bengals at Ravens on Thanksgiving

Austan Kas

• 5d

2 Best NFL Bets and Player Props for Bengals at Ravens on Thanksgiving

2 Best NFL Bets and Predictions for Thanksgiving Day

Jim Sannes

• 5d

2 Best NFL Bets and Predictions for Thanksgiving Day

San Francisco 49ers

DateOpponentResultSpread

@

CLEW 26 - 8-5.5

vs

CARW 9 - 20-7.5

@

ARIW 41 - 22-3

vs

LARL 42 - 26+3.5

@

NYGW 34 - 24-2.5

@

HOUL 15 - 26-1.5

Indianapolis Colts

DateOpponentResultSpread

vs

HOUL 20 - 16-3

@

KCL 20 - 23+3.5

vs

ATLW 25 - 31-5.5

@

PITL 20 - 27-3

vs

TENW 14 - 38-14.5

@

LACW 38 - 24+1.5

SF

IND

-

Offensive EPA

-

-

Passing EPA

-

-

Rushing EPA

-

-

Defensive EPA

-

-

Def Pass EPA

-

-

Def Rush EPA

-

San Francisco 49ers

NameStatus

FBKyle Juszczyk

QRibs

WRTrent Taylor

IRUndisclosed

LBFred Warner

IRAnkle

DLKevin Givens

PUPCoach's Decision

KEddy Pineiro

PUPHamstring

RBPatrick Taylor Jr.

IRShoulder

Indianapolis Colts

NameStatus

DTDeForest Buckner

IRNeck

OLBJacob Phillips

IRBiceps

RBSalvon Ahmed

IRAnkle

SAFDaniel Scott

IRKnee

TEWill Mallory

PUPCoach's Decision

WRD.J. Montgomery

IRUndisclosed

San Francisco 49ers Vs. Indianapolis Colts Odds, Betting Lines, Score & Stats (December 22, 2025) | FanDuel Research