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San Francisco 49ers Vs. Cleveland Browns Odds, Betting Lines, Score & Stats (November 30, 2025) | FanDuel Research

FanDuel Research>
NFL>
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San Francisco 49ers Vs. Cleveland Browns

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4 Leg Parlay

+2000

Player

Any Time Touchdown Scorer

Player 40+ Yards

Player - Alt Rushing Yds

Player 250+ Yards

Player - Alt Passing Yds

Player 5+ Receptions

Player - Alt Receptions

1425 People Placed

4 Leg Parlay

+2000

Player

Any Time Touchdown Scorer

Player 40+ Yards

Player - Alt Rushing Yds

Player 250+ Yards

Player - Alt Passing Yds

Player 5+ Receptions

Player - Alt Receptions

1425 People Placed

Thanksgiving Pass The Leg NFL Parlay/SGP Profit Boost

College Basketball Parlay Profit Boost

Bet $5, Get $150 if You Win!

This Thanksgiving, Pass The Leg

San Francisco 49ers

RBChristian McCaffrey

24.6 Points

16.6 Points

TEGeorge Kittle

10.3 Points

WRJauan Jennings

9.5 Points

Cleveland Browns

QBShedeur Sanders

13.1 Points

RBQuinshon Judkins

12.4 Points

TEHarold Fannin Jr.

8.3 Points

7.0 Points

SF

CLE

6.792

Offensive EPA

-7.48

11.5464

Passing EPA

-13.6

2.0376

Rushing EPA

0.68

8.1504

Defensive EPA

-2.72

11.5464

Def Pass EPA

-2.72

5.4336

Def Rush EPA

-4.76

CBS

San Francisco 49ers

8-4 | 3rd in NFC West | 7th in NFC

SpreadMoneylineTotal

@

Cleveland Browns

3-8 | 4th in AFC North | 13th in AFC

SpreadMoneylineTotal

CBS

Huntington Bank Field

San Francisco 49ers

NameStatus

WRTrent Taylor

IRUndisclosed

LBFred Warner

IRAnkle

KEddy Pineiro

QHamstring

RBPatrick Taylor Jr.

IRShoulder

DLNick Bosa

IRKnee - ACL

DLYetur Gross-Matos

IRKnee

Cleveland Browns

NameStatus

WRDeAndre Carter

IRKnee

LBNathaniel Watson

IRBiceps

DEAlex Wright

QQuadriceps

CBMartin Emerson Jr.

IRAchilles

WRJamari Thrash

QFoot

DTAdin Huntington

QGroin

Line Movement

These graphs show how the spread, moneyline, and total have shifted at FanDuel Sportsbook over time.

Spread

49ers

Open: -7

Browns

Open: +7

Moneyline

49ers

Open: -340

Browns

Open: +275

Total

Over

Open: 42.5

Under

Open: 42.5

Type

Passing Yards

Receiving Yards

Rushing Yards

Passing Touchdowns

Shedeur Sanders

QB • 128 Average YD

Brock Purdy

QB • 245 Average YD

San Francisco 49ers

DateOpponentResultSpread

vs

CARW 9 - 20-7.5

@

ARIW 41 - 22-3

vs

LARL 42 - 26+3.5

@

NYGW 34 - 24-2.5

@

HOUL 15 - 26-1.5

vs

ATLW 10 - 20-3

Cleveland Browns

DateOpponentResultSpread

@

LVW 24 - 10+3.5

vs

BALL 23 - 16+8.5

@

NYJL 20 - 27+1.5

@

NEL 13 - 32+7

vs

MIAW 6 - 31-2.5

@

PITL 9 - 23+5.5