NFL Games This Week: Predictions, Odds, Picks, Best Bets for Week 10

The Week 10 NFL schedule has plenty of quality competition on the docket. Among those contests is the Los Angeles Rams squaring off against the San Francisco 49ers.

With Week 10 in the NFL upon us, stay on top of the latest betting trends with our preview below.

Broncos vs. Raiders

Bo Nix will lead the Denver Broncos (7-2) into their matchup versus the Las Vegas Raiders (2-6) at Empower Field at Mile High on Thursday at 8:15 p.m. ET.

• Game Preview: Las Vegas Raiders at Denver Broncos
• Projected Favorite: Broncos (81.80% win probability)
• Spread: Denver (-9.5)
• Total: 42.5 -- Over: (-108) | Under: (-112)
• Time: 8:15 p.m. ET
• Channel: Amazon Prime Video

Bet on Denver vs. Las Vegas with FanDuel Sportsbook.

Colts vs. Falcons

Bijan Robinson and the Atlanta Falcons (3-5) will get a stiff test when they square off against the Indianapolis Colts (7-2), who have the NFL's fourth-best run D, on Sunday, Nov. 9 at 9:30 a.m. ET. Robinson ranks 10th-best in the league in rushing yards.

• Game Preview: Atlanta Falcons vs. Indianapolis Colts
• Projected Favorite: Colts (77.27% win probability)
• Spread: Indianapolis (-6.5)
• Total: 48.5 -- Over: (-105) | Under: (-115)
• Time: 9:30 a.m. ET
• Channel: NFL Network

Bet on Indianapolis vs. Atlanta with FanDuel Sportsbook.

Vikings vs. Ravens

At 1 p.m. ET on Sunday, the Baltimore Ravens (3-5) play at the Minnesota Vikings (4-4).

• Game Preview: Baltimore Ravens at Minnesota Vikings
• Projected Favorite: Ravens (62.20% win probability)
• Spread: Baltimore (-4.5)
• Total: 47.5 -- Over: (-120) | Under: (-102)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Minnesota vs. Baltimore with FanDuel Sportsbook.

Jets vs. Browns

On Sunday, Nov. 9 at 1 p.m. ET, the Cleveland Browns (2-6) will attempt to bounce back from their recent 32-13 loss to the Patriots when they go head to head against the New York Jets (1-7) at MetLife Stadium. The Jets won their previous game 39-38 versus the Bengals.

• Game Preview: Cleveland Browns at New York Jets
• Projected Favorite: Jets (50.21% win probability)
• Spread: Cleveland (-2.5)
• Total: 37.5 -- Over: (-115) | Under: (-105)
• Time: 1 p.m. ET
• Channel: CBS

Bet on New York vs. Cleveland with FanDuel Sportsbook.

Texans vs. Jaguars

At NRG Stadium on Sunday, the Houston Texans (3-5) take on the Jacksonville Jaguars (5-3).

• Game Preview: Jacksonville Jaguars at Houston Texans
• Projected Favorite: Texans (63.36% win probability)
• Spread: Houston (-1.5)
• Total: 38.5 -- Over: (-110) | Under: (-110)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Houston vs. Jacksonville with FanDuel Sportsbook.

Buccaneers vs. Patriots

Emeka Egbuka and the Tampa Bay Buccaneers (6-2) will host Drake Maye and the New England Patriots (7-2) on Sunday at 1 p.m. ET, in a battle featuring a pair of the biggest offensive stars in football.

• Game Preview: New England Patriots at Tampa Bay Buccaneers
• Projected Favorite: Buccaneers (57.03% win probability)
• Spread: Tampa Bay (-2.5)
• Total: 48.5 -- Over: (-104) | Under: (-118)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Tampa Bay vs. New England with FanDuel Sportsbook.

Bears vs. Giants

At 1 p.m. ET on Sunday, the New York Giants (2-7) play at the Chicago Bears (5-3).

• Game Preview: New York Giants at Chicago Bears
• Projected Favorite: Bears (70.46% win probability)
• Spread: Chicago (-3.5)
• Total: 48.5 -- Over: (-105) | Under: (-115)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Chicago vs. New York with FanDuel Sportsbook.

Panthers vs. Saints

The Carolina Panthers (5-4), who defeated the Packers in their last contest, host the New Orleans Saints (1-8) at Bank of America Stadium on Nov. 9 at 1 p.m. ET. The Saints were taken down by the Rams in their last game.

• Game Preview: New Orleans Saints at Carolina Panthers
• Projected Favorite: Panthers (75.63% win probability)
• Spread: Carolina (-5.5)
• Total: 39.5 -- Over: (-112) | Under: (-108)
• Time: 1 p.m. ET
• Channel: FOX

Bet on Carolina vs. New Orleans with FanDuel Sportsbook.

Dolphins vs. Bills

Two of the top offensive performers in football will be featured when wideout Dalton Kincaid and the Buffalo Bills (6-2) visit running back De'Von Achane and the Miami Dolphins (2-7) on Sunday, November 9, 2025.

• Game Preview: Buffalo Bills at Miami Dolphins
• Projected Favorite: Bills (72.51% win probability)
• Spread: Buffalo (-9.5)
• Total: 49.5 -- Over: (-120) | Under: (-102)
• Time: 1 p.m. ET
• Channel: CBS

Bet on Miami vs. Buffalo with FanDuel Sportsbook.

Seahawks vs. Cardinals

Jaxon Smith-Njigba will lead the Seattle Seahawks (6-2) into their battle versus the Arizona Cardinals (3-5) at Lumen Field on Sunday at 4:05 p.m. ET.

• Game Preview: Arizona Cardinals at Seattle Seahawks
• Projected Favorite: Seahawks (74.55% win probability)
• Spread: Seattle (-6.5)
• Total: 45.5 -- Over: (-115) | Under: (-105)
• Time: 4:05 p.m. ET
• Channel: CBS

Bet on Seattle vs. Arizona with FanDuel Sportsbook.

49ers vs. Rams

The Los Angeles Rams (6-2), who took home the victory against the Saints in their last game, visit the San Francisco 49ers (6-3) at Levi's Stadium on Nov. 9 at 4:25 p.m. ET. The 49ers picked up the W against the Giants in their last game.

• Game Preview: Los Angeles Rams at San Francisco 49ers
• Projected Favorite: Rams (63.34% win probability)
• Spread: Los Angeles (-3.5)
• Total: 50.5 -- Over: (-105) | Under: (-115)
• Time: 4:25 p.m. ET
• Channel: FOX

Bet on San Francisco vs. Los Angeles with FanDuel Sportsbook.

Commanders vs. Lions

The Detroit Lions (5-3) and Amon-Ra St. Brown, one of the league's top pass-catchers, should have a productive day through the air on Sunday, as the Washington Commanders (3-6) own the 29th-ranked pass defense in the NFL. The two teams will compete at 4:25 p.m. ET on Nov. 9.

• Game Preview: Detroit Lions at Washington Commanders
• Projected Favorite: Lions (70.26% win probability)
• Spread: Detroit (-8.5)
• Total: 49.5 -- Over: (-108) | Under: (-112)
• Time: 4:25 p.m. ET
• Channel: FOX

Bet on Washington vs. Detroit with FanDuel Sportsbook.

Matchup favorites and win projections are provided by numberFire.

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