Nebraska vs Michigan State Prediction, Odds, Picks, Best Bets for Week 6 2025

The Nebraska Cornhuskers are among the college football teams busy on Saturday, versus the Michigan State Spartans.

Get the latest NCAA football odds ahead of this matchup on FanDuel Sportsbook.

Nebraska vs Michigan State Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Nebraska: (-465) | Michigan State: (+350)
• Spread: Nebraska: -10.5 (-115) | Michigan State: +10.5 (-105)
• Total: 48.5 -- Over: (-115) | Under: (-105)

Nebraska vs Michigan State Betting Trends

• Nebraska has two wins against the spread this season.
• Nebraska is unbeaten ATS (2-0) as a 10.5-point favorite or greater this season.
• Nebraska has played four games this season, and three of them have hit the over.
• Michigan State has one win against the spread this year.
• Michigan State is unbeaten ATS (1-0) as a 10.5-point underdog or greater this year.
• There have been three Michigan State games (out of four) that hit the over this season.

Nebraska vs Michigan State Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Cornhuskers win (73.6%)

Nebraska vs Michigan State Point Spread

Nebraska is favored by 10.5 points (-115 to cover) in this matchup. Michigan State, the underdog, is -105.

Nebraska vs Michigan State Over/Under

The over/under for Nebraska-Michigan State on Oct. 4 is 48.5. The over is -115, and the under is -105.

Nebraska vs Michigan State Moneyline

Michigan State is the underdog, +350 on the moneyline, while Nebraska is a -465 favorite.

Nebraska vs. Michigan State Points Insights

Nebraska vs. Michigan State Game Info

• Game day: Saturday, October 4, 2025
• Game time: 4 p.m. ET
• TV channel: Fox Sports 1
• Location: Lincoln, Nebraska
• Stadium: Memorial Stadium (Lincoln, NE)

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Check out even more in-depth Nebraska vs. Michigan State analysis on FanDuel Research.