Nationals vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 27

Odds updated as of 5:13 a.m.

MLB action on Saturday includes the Washington Nationals playing the Chicago White Sox.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Nationals vs White Sox Game Info

• Washington Nationals (65-95) vs. Chicago White Sox (59-101)
• Date: Saturday, September 27, 2025
• Time: 4:05 p.m. ET
• Venue: Nationals Park -- Washington, District of Columbia
• Coverage: MASN2 and CHSN

Nationals vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: WSH: (-120) | CHW: (+102)
• Spread: WSH: +1.5 (-196) | CHW: -1.5 (+162)
• Total: 8.5 -- Over: (-110) | Under: (-110)

Nationals vs White Sox Probable Starting Pitchers

Probable Pitchers: Jake Irvin (Nationals) - 9-13, 5.69 ERA vs Sean Burke (White Sox) - 4-11, 4.29 ERA

The probable pitchers are Jake Irvin (9-13) for the Nationals and Sean Burke (4-11) for the White Sox. Irvin's team is 16-15-0 against the spread this season in his starts. Irvin's team lost his only start as a favorite this season. When Burke starts, the White Sox have gone 13-9-0 against the spread. The White Sox have been the moneyline underdog in 22 of Burke's starts this season, and they went 9-13 in those games.

Nationals vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Nationals win (51.8%)

Nationals vs White Sox Moneyline

• Washington is the favorite, -120 on the moneyline, while Chicago is a +102 underdog on the road.

Nationals vs White Sox Spread

• The White Sox are 1.5-run favorites against the spread for this matchup with the Nationals. The White Sox are +162 to cover, while the Nationals are -196 to cover as a 1.5-run underdog on the runline.

Nationals vs White Sox Over/Under

• Nationals versus White Sox, on Sept. 27, has an over/under of 8.5, with the over being -110 and the under -110.

Bet on Washington Nationals vs. Chicago White Sox on FanDuel today!

Nationals vs White Sox Betting Trends

• The Nationals have come away with six wins in the 19 contests they have been listed as the favorites in this season.
• This year Washington has won two of 10 games when listed as at least -120 on the moneyline.
• The Nationals and their opponents have hit the over in 82 of their 154 games with a total set by oddsmakers this season.
• The Nationals have an against the spread mark of 76-78-0 in 154 games with a line this season.
• The White Sox have been the moneyline underdog 151 total times this season. They've gone 55-96 in those games.
• When playing as a moneyline underdog with odds of +102 or longer, Chicago has a 53-92 record (winning just 36.6% of its games).
• The White Sox have played in 155 games with an over/under set, and have combined with opponents to go over the total 71 times (71-76-8).
• The White Sox have put together an 88-67-0 record against the spread this season.

Nationals Player Leaders

• C.J. Abrams has 35 doubles, five triples, 19 home runs and 37 walks while hitting .260. He has an on-base percentage of .319 and a slugging percentage of .439.
• Among qualified batters in MLB, his batting average ranks 68th, his on-base percentage ranks 98th, and he is 67th in slugging.
• Abrams will look for his fourth straight game with a hit in this contest. During his last five outings he is hitting .182 with a double, a home run, a walk and two RBIs.
• James Wood leads Washington in OBP (.349), slugging percentage (.471) and total hits (150) this season. He's batting .254.
• His batting average ranks 87th among qualified players, his on-base percentage 42nd, and his slugging percentage 40th.
• Luis Garcia has 123 hits this season and has a slash line of .255/.291/.417.
• Josh Bell is batting .238 with a .324 OBP and 63 RBI for Washington this season.
• Bell enters this matchup on a two-game hitting streak. During his last five outings he is hitting .429 with a double, two home runs, a walk and two RBIs.

White Sox Player Leaders

• Miguel Vargas is batting .233 with 32 doubles, two triples, 15 home runs and 54 walks. He's slugging .396 with an on-base percentage of .314.
• Including all the qualifying hitters in MLB, his batting average ranks 129th, his on-base percentage ranks 106th, and he is 109th in slugging.
• Vargas heads into this game on a seven-game hitting streak. In his last 10 outings he is hitting .257 with a double, a home run, four walks and five RBIs.
• Lenyn Sosa leads his team with 134 hits and has a club-best .433 slugging percentage. He has a batting average of .263 with an on-base percentage of .292.
• Including all qualifying hitters, he ranks 58th in batting average, 132nd in on-base percentage and 73rd in slugging percentage.
• Chase Meidroth has accumulated an on-base percentage of .333, a team-best for the White Sox.
• Colson Montgomery is batting .231 with eight doubles, a triple, 20 home runs and 24 walks.

Nationals vs White Sox Head to Head

• 9/26/2025: 10-9 CHW (Favorite: Nationals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 5/15/2024: 2-0 CHW (Favorite: White Sox, Spread: -1.5, Total: 7, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 5/14/2024: 4-0 CHW (Favorite: Nationals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/14/2024: 6-3 WSH (Favorite: Nationals, Spread: -1.5, Total: 8, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 9/20/2023: 13-3 WSH (Favorite: Nationals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 9/19/2023: 4-3 WSH (Favorite: Nationals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 9/18/2023: 6-1 CHW (Favorite: White Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -124, Underdog Moneyline: +106)

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