Missouri vs Ole Miss Prediction, Picks, Player Props, Odds and Best Bets Today 10/17/26

Missouri vs Ole Miss Prediction in Summary

• Ole Miss -3.5
• Over 58.5
• Ole Miss Over 436.5 Total Yards
• Missouri Over 405.5 Total Yards
• Prediction: Ole Miss wins a close, high-scoring game

Missouri travels to Ole Miss Saturday, and the total alone tells the story — at 58.5, it's one of the highest you'll find on this week's slate. The market sees a modest home favorite in a matchup both offenses should move the ball well in.

All college football odds come from FanDuel Sportsbook's college football betting odds and may change after this article is published.

Missouri vs Ole Miss Odds & Best Bets

Missouri at Ole Miss (Sat, 3:30 p.m. ET)

Ole Miss -3.5 (-120)

A modest home favorite in a genuinely close matchup — Ole Miss's own yardage line (436.5) sits just 31 yards ahead of Missouri's (405.5), a fair reflection of the number.

Over 58.5 (-108)

One of the highest totals of the entire college football slate this week, a real sign the market expects both offenses to find the end zone with real regularity.

Ole Miss 436.5+ Total Yards (-114)

Ole Miss carries the higher projected yardage line of the two offenses on this board, a real sign the home team is expected to move the ball consistently today.

Missouri 405.5+ Total Yards (-114)

Missouri's own yardage line also sits well above 400, a real sign the road team is expected to put together a genuinely productive offensive day of its own.

Missouri vs Ole Miss Prediction

With both teams carrying real production north of 400 projected yards and the total sitting among the highest of the week, expect a genuine shootout in this SEC matchup. Ole Miss's slight home-field edge is the deciding factor here — look for the Rebels to cover behind a real, productive offensive day, with the total pushing well past 58 as both sides trade scores throughout.