Mississippi State vs Vanderbilt Prediction, Odds, Picks, Best Bets for Week 10 2026

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In college football action on Saturday, the Mississippi State Bulldogs face the Vanderbilt Commodores.

Get the latest NCAA football odds ahead of this matchup on FanDuel Sportsbook.

Mississippi State vs Vanderbilt Odds & Spread

All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
Moneyline: Mississippi State: (-156) | Vanderbilt: (+130)
Spread: Mississippi State: -2.5 (-138) | Vanderbilt: +2.5 (112)
Total: 48.5 -- Over: (-110) | Under: (-110)

Mississippi State is 4-4-0 against the spread this year.
Mississippi State is unbeaten ATS (2-0) as a 2.5-point favorite or greater this season.
There have been three Mississippi State games (of eight) that went over the total this season.
Vanderbilt has three wins in eight contests against the spread this year.
Vanderbilt has two wins ATS (2-2) as a 2.5-point underdog or greater this year.
Of eight Vanderbilt games so far this season, five have gone over the total.

All college football win probability predictions and picks are according to numberFire.
Prediction: Bulldogs win (82.4%)

Vanderbilt is an underdog by 2.5 points against Mississippi State. Vanderbilt is +112 to cover the spread, and Mississippi State is -138.

A total of 48.5 points has been set for the Mississippi State-Vanderbilt game on Nov. 7, with the over available at -110 and the under at -110.

Vanderbilt is a +130 underdog on the moneyline, while Mississippi State is a -156 favorite.

	Point Scored (PG)	Points Scored CFB Rank	Points Allowed (PG)	Points Allowed CFB Rank	Average Total	Total Games
Mississippi State	26.6	86	28.1	98	55.6	8
Vanderbilt	22.8	109	30.3	110	52.8	8

Check out even more in-depth Mississippi State vs. Vanderbilt analysis on FanDuel Research.

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