Mariners vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 26

Odds updated as of 6:12 a.m.

MLB action on Tuesday includes the Seattle Mariners playing the San Diego Padres.

We've got you covered, in terms of the most important information about this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Mariners vs Padres Game Info

• Seattle Mariners (71-61) vs. San Diego Padres (74-58)
• Date: Tuesday, August 26, 2025
• Time: 9:40 p.m. ET
• Venue: T-Mobile Park -- Seattle, Washington
• Coverage: ROOT Sports NW and SDPA

Mariners vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SEA: (-112) | SD: (-104)
• Spread: SEA: +1.5 (-205) | SD: -1.5 (+168)
• Total: 7.5 -- Over: (-120) | Under: (-102)

Mariners vs Padres Probable Starting Pitchers

Probable Pitchers: Luis Castillo (Mariners) - 8-7, 3.57 ERA vs Dylan Cease (Padres) - 6-11, 4.71 ERA

The Mariners will give the nod to Luis Castillo (8-7) versus the Padres and Dylan Cease (6-11). Castillo and his team have a record of 11-15-0 against the spread when he starts. Castillo's team has been victorious in 57.9% of the games he's started as the moneyline favorite with a record of 11-8. The Padres have a 12-14-0 record against the spread in Cease's starts. The Padres are 2-5 in Cease's seven starts this season that they were the underdog on the moneyline.

Mariners vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (50.2%)

Mariners vs Padres Moneyline

• Looking at the moneyline for Mariners-Padres, Seattle is the favorite at -112, and San Diego is -104 playing on the road.

Mariners vs Padres Spread

• The Padres are 1.5-run favorites against the spread for this matchup with the Mariners. The Padres are +168 to cover, while the Mariners are -205 to cover as a 1.5-run underdog on the runline.

Mariners vs Padres Over/Under

• The over/under for Mariners-Padres on Aug. 26 is 7.5. The over is -120, and the under is -102.

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Mariners vs Padres Betting Trends

• The Mariners have been chosen as favorites in 87 games this year and have walked away with the win 50 times (57.5%) in those games.
• This season Seattle has been victorious 50 times in 85 chances when named as a favorite of at least -112 on the moneyline.
• The Mariners and their opponents have gone over the total this season in 67 of their 127 opportunities.
• The Mariners are 54-73-0 against the spread in their 127 games with a line set by sportsbooks this season.
• The Padres have won 29 of the 59 games they were listed as the moneyline underdog this season (49.2%).
• San Diego has gone 28-29 when it has played as a moneyline underdog with odds of -104 or longer (49.1%).
• The Padres have played in 130 games with a set over/under, and have combined with their opponents to go over the total 56 times (56-71-3).
• The Padres have a 73-57-0 record against the spread this season.

Mariners Player Leaders

• Cal Raleigh leads Seattle in total hits (120) this season while batting .247 with 69 extra-base hits. He has an on-base percentage of .353 and a slugging percentage of .596.
• Among all qualified hitters in MLB, he is 104th in batting average, 38th in on-base percentage, and third in slugging.
• Raleigh hopes to build on a two-game hitting streak in this matchup. In his last five games he is hitting .200 with three home runs and five RBIs.
• Josh Naylor is hitting .284 with 24 doubles, a triple, 16 home runs and 43 walks. He's slugging .450 with an on-base percentage of .348.
• He is 26th in batting average, 46th in on-base percentage and 67th in slugging in MLB.
• Naylor brings a four-game streak with at least one hit into this matchup. During his last five outings he is batting .313 with a double, a home run, a walk and four RBIs.
• Julio Rodriguez leads Seattle in slugging percentage (.457) powered by 53 extra-base hits.
• Rodriguez has picked up a hit in two games in a row. In his last five games he is hitting .278 with a double, a home run, a walk and three RBIs.
• Eugenio Suarez has been key for Seattle with 110 hits, an OBP of .306 plus a slugging percentage of .538.

Padres Player Leaders

• Fernando Tatis Jr. a has .372 on-base percentage to lead the Padres. He's batting .263 while slugging .433.
• Including all the qualified hitters in the majors, his batting average is 61st, his on-base percentage ranks 13th, and he is 79th in slugging.
• Manny Machado has racked up 147 hits while slugging .475. Both are team-highs. He has a batting average of .289 with an on-base percentage of .350.
• He ranks 20th in batting average, 41st in on-base percentage and 39th in slugging percentage in the big leagues.
• Luis Arraez has a .393 slugging percentage, which leads the Padres.
• Xander Bogaerts is hitting .262 with 29 doubles, 10 home runs and 48 walks.

Mariners vs Padres Head to Head

• 8/25/2025: 9-6 SEA (Favorite: Mariners, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/18/2025: 6-1 SEA (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/17/2025: 4-1 SEA (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 5/16/2025: 5-1 SEA (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 9/11/2024: 5-2 SEA (Favorite: Mariners, Spread: -1.5, Total: 6.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 9/10/2024: 7-3 SD (Favorite: Mariners, Spread: -1.5, Total: 7, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/10/2024: 2-0 SEA (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 7/9/2024: 8-3 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 8/9/2023: 6-1 SEA (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 8/8/2023: 2-0 SEA (Favorite: Mariners, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)

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