Mariners vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for May 15

Odds updated as of 7:11 a.m.

On Friday in MLB, the Seattle Mariners are up against the San Diego Padres.

We've got you covered, in terms of the most important info regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Mariners vs Padres Game Info

• Seattle Mariners (22-23) vs. San Diego Padres (25-18)
• Date: Friday, May 15, 2026
• Time: 9:40 p.m. ET
• Venue: T-Mobile Park -- Seattle, Washington
• Coverage: Mariners.TV and Padres.TV

Mariners vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SEA: (-138) | SD: (+118)
• Spread: SEA: -1.5 (+150) | SD: +1.5 (-182)
• Total: 7.5 -- Over: (+102) | Under: (-124)

Mariners vs Padres Probable Starting Pitchers

Probable Pitchers: Emerson Hancock (Mariners) - 3-1, 3.21 ERA vs Randy Vasquez (Padres) - 4-1, 3.05 ERA

The Mariners will give the nod to Emerson Hancock (3-1) versus the Padres and Randy Vasquez (4-1). Hancock's team is 3-5-0 against the spread in his starts this season. When Hancock starts a game and his team is the favorite on the moneyline, they have a record of 4-3. The Padres have a 6-2-0 ATS record in Vasquez's eight starts with a set spread. The Padres were the moneyline underdog for one Vasquez start this season -- they won.

Mariners vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Mariners win (53.9%)

Mariners vs Padres Moneyline

• Seattle is a -138 favorite on the moneyline, while San Diego is a +118 underdog on the road.

Mariners vs Padres Spread

• The Padres are at +1.5 on the runline against the Mariners. The Padres are -182 to cover the spread, and the Mariners are +150.

Mariners vs Padres Over/Under

• Mariners versus Padres on May 15 has an over/under of 7.5 runs, with the odds on the over +102 and the under set at -124.

Bet on Seattle Mariners vs. San Diego Padres on FanDuel today!

Mariners vs Padres Betting Trends

• The Mariners have been chosen as favorites in 41 games this year and have walked away with the win 21 times (51.2%) in those games.
• This year Seattle has won 13 of 21 games when listed as at least -138 on the moneyline.
• The Mariners and their opponents have gone over the total this season in 20 of their 45 opportunities.
• The Mariners are 17-28-0 against the spread in their 45 games with a line set by sportsbooks this season.
• The Padres have won 50% of the games this season they were the underdog on the moneyline (8-8).
• San Diego is 4-2 (winning 66.7% of its games) when it has played as a moneyline underdog of +118 or longer.
• The Padres have played in 43 games with a set over/under, and have combined with opponents to go over the total 18 times (18-24-1).
• The Padres have a 23-20-0 record ATS this season (covering 53.5% of the time).

Mariners Player Leaders

• Randy Arozarena leads Seattle with 49 hits and an OBP of .389, plus a team-best slugging percentage of .454. He's batting .301.
• Among all qualified batters in baseball, he is 19th in batting average, 14th in on-base percentage, and 53rd in slugging.
• Julio Rodriguez has nine doubles, seven home runs and 15 walks. He's batting .261 and slugging .428 with an on-base percentage of .325.
• He is 66th in batting average, 97th in on-base percentage and 62nd in slugging in the major leagues.
• J.P. Crawford has 28 hits this season and has a slash line of .215/.363/.362.
• Crawford heads into this matchup with three games in a row with at least one hit. In his last five games he is hitting .286 with a double, a home run, two walks and four RBIs.
• Josh Naylor is batting .247 with a .311 OBP and 20 RBI for Seattle this season.
• Naylor has safely hit in three games in a row. In his last five games he is hitting .250 with two doubles and three walks.

Padres Player Leaders

• Xander Bogaerts has accumulated an on-base percentage of .331, a slugging percentage of .414, and has 39 hits, all club-highs for the Padres (while batting .257).
• Including all the qualified hitters in the majors, his batting average is 77th, his on-base percentage is 85th, and he is 74th in slugging.
• Manny Machado is batting .190 with four doubles, six home runs and 21 walks. He's slugging .340 with an on-base percentage of .287.
• Including all qualified players, his batting average places him 159th, his on-base percentage ranks 140th, and he is 138th in slugging.
• Jackson Merrill has eight doubles, four home runs and 15 walks while hitting .215.
• Gavin Sheets has nine doubles, six home runs and nine walks while hitting .229.

Mariners vs Padres Head to Head

• 4/16/2026: 5-2 SD (Favorite: Mariners, Spread: -1.5, Total: 8.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 4/15/2026: 7-6 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 4/14/2026: 4-1 SD (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 8/27/2025: 4-3 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 8/26/2025: 7-6 SD (Favorite: Mariners, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/25/2025: 9-6 SEA (Favorite: Mariners, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/18/2025: 6-1 SEA (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/17/2025: 4-1 SEA (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 5/16/2025: 5-1 SEA (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 9/11/2024: 5-2 SEA (Favorite: Mariners, Spread: -1.5, Total: 6.5, Favorite Moneyline: -108, Underdog Moneyline: -108)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!