Mariners vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 10

Odds updated as of 10:14 a.m.

The Seattle Mariners will face the St. Louis Cardinals in MLB action on Wednesday.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information about this matchup.

Mariners vs Cardinals Game Info

• Seattle Mariners (77-68) vs. St. Louis Cardinals (72-74)
• Date: Wednesday, September 10, 2025
• Time: 9:40 p.m. ET
• Venue: T-Mobile Park -- Seattle, Washington
• Coverage: ROOT Sports NW and FDSMW

Mariners vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SEA: (-225) | STL: (+188)
• Spread: SEA: -1.5 (-104) | STL: +1.5 (-115)
• Total: 7.5 -- Over: (-102) | Under: (-120)

Mariners vs Cardinals Probable Starting Pitchers

Probable Pitchers: Logan Gilbert (Mariners) - 4-6, 3.61 ERA vs Michael McGreevy (Cardinals) - 6-3, 4.68 ERA

This contest's pitching matchup is set, as the Mariners will send Logan Gilbert (4-6) to the mound, while Michael McGreevy (6-3) will answer the bell for the Cardinals. Gilbert and his team are 6-14-0 ATS this season when he starts. Gilbert's team has been victorious in 68.8% of the games he's started as the moneyline favorite with a record of 11-5. The Cardinals have a 7-5-0 ATS record in McGreevy's 12 starts with a set spread. The Cardinals have been the underdog on the moneyline in six of McGreevy's starts this season, and they went 5-1 in those games.

Mariners vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Mariners win (65%)

Mariners vs Cardinals Moneyline

• St. Louis is a +188 underdog on the moneyline, while Seattle is a -225 favorite at home.

Mariners vs Cardinals Spread

• The Mariners are 1.5-run home favorites on the runline against the Cardinals. The Mariners are -104 to cover, and the Cardinals are -115.

Mariners vs Cardinals Over/Under

• Mariners versus Cardinals on Sept. 10 has an over/under of 7.5 runs, with the odds on the over -102 and the under set at -120.

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Mariners vs Cardinals Betting Trends

• The Mariners have won in 55, or 56.1%, of the 98 contests they have been named as odds-on favorites in this year.
• This season Seattle has been victorious four times in five chances when named as a favorite of at least -225 on the moneyline.
• The Mariners and their opponents have hit the over in 75 of their 140 games with a total set by oddsmakers this season.
• In 140 games with a line this season, the Mariners have a mark of 60-80-0 against the spread.
• The Cardinals have won 37 of the 76 games they were the moneyline underdog this season (48.7%).
• St. Louis has played as a moneyline underdog of +188 or longer in just one game this season, which it lost.
• In the 140 games oddsmakers have set an over/under for the Cardinals, they have combined with opponents to go over the total 72 times (72-63-5).
• The Cardinals are 70-70-0 ATS this season.

Mariners Player Leaders

• Cal Raleigh has 128 hits, which ranks first among Seattle hitters this season, while batting .240 with 72 extra-base hits. He has an on-base percentage of .349 and a slugging percentage of .574.
• He is 113th in batting average, 39th in on-base percentage, and third in slugging among qualified hitters in baseball.
• Julio Rodriguez has an OPS of .793, fueled by an OBP of .317 and a team-best slugging percentage of .476 this season. He's batting .266.
• His batting average ranks 51st among qualified players, his on-base percentage 100th, and his slugging percentage 33rd.
• Josh Naylor has collected 140 base hits, an OBP of .348 and a slugging percentage of .458 this season.
• Naylor has picked up a hit in four games in a row. During his last five outings he is hitting .467 with a double, three home runs, a walk and seven RBIs.
• Eugenio Suarez has been key for Seattle with 122 hits, an OBP of .307 plus a slugging percentage of .543.

Cardinals Player Leaders

• Alec Burleson has accumulated a slugging percentage of .457 and has 125 hits, both team-best numbers for the Cardinals. He's batting .285 and with an on-base percentage of .335.
• Including all the qualifying players in the majors, he ranks 19th in batting average, 60th in on-base percentage and 54th in slugging percentage.
• Willson Contreras is batting .256 with 30 doubles, a triple, 20 home runs and 42 walks. He's slugging .449 with an on-base percentage of .339.
• He is currently 81st in batting average, 52nd in on-base percentage and 62nd in slugging percentage among all qualified hitters.
• Masyn Winn is batting .253 with 27 doubles, nine home runs and 34 walks.
• Lars Nootbaar is hitting .241 with 22 doubles, a triple, 13 home runs and 56 walks.

Mariners vs Cardinals Head to Head

• 9/9/2025: 5-3 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 9/8/2025: 4-2 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -250, Underdog Moneyline: +205)
• 9/8/2024: 10-4 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 9/7/2024: 2-0 STL (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/6/2024: 6-1 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/23/2023: 7-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 4/22/2023: 5-4 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 4/21/2023: 5-2 SEA (Favorite: Mariners, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)

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