Mariners vs Astros Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 23

Odds updated as of 4:11 a.m.

The Wednesday schedule in MLB includes a matchup between the Seattle Mariners and the Houston Astros.

We've got you covered, in terms of the vital info about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Mariners vs Astros Game Info

• Seattle Mariners (73-84) vs. Houston Astros (78-79)
• Date: Wednesday, September 23, 2026
• Time: 10:10 p.m. ET
• Venue: T-Mobile Park -- Seattle, Washington
• Coverage: ESPN

Mariners vs Astros Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SEA: (-146) | HOU: (+124)
• Spread: SEA: -1.5 (+142) | HOU: +1.5 (-172)
• Total: 8.5 -- Over: (+108) | Under: (-132)

Mariners vs Astros Probable Starting Pitchers

Probable Pitchers: George Kirby (Mariners) - 9-11, 4.24 ERA vs Ethan Pecko (Astros) - 1-0, 3.77 ERA

The Mariners will give the ball to George Kirby (9-11, 4.24 ERA), who is eyeing win No. 10 on the season, and the Astros will counter with Ethan Pecko (1-0, 3.77 ERA). Kirby's team is 10-19-0 against the spread in his starts this season. When Kirby starts a game and his team is the favorite on the moneyline, they have a record of 13-13. The Astros have a 3-1-0 record against the spread in Pecko's starts. The Astros were the moneyline underdog for two Pecko starts this season -- they won both.

Mariners vs Astros Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Mariners win (61.9%)

Mariners vs Astros Moneyline

• The Mariners vs Astros moneyline has Seattle as a -146 favorite, while Houston is a +124 underdog on the road.

Mariners vs Astros Spread

• The Mariners are hosting the Astros and are favored by 1.5 runs (+142 to cover) on the runline. Houston is -172 to cover.

Mariners vs Astros Over/Under

• Mariners versus Astros, on Sept. 23, has an over/under of 8.5, with the over being +108 and the under -132.

Bet on Seattle Mariners vs. Houston Astros on FanDuel today!

Mariners vs Astros Betting Trends

• The Mariners have come away with 59 wins in the 120 contests they have been listed as the favorites in this season.
• This season Seattle has come away with a win 28 times in 48 chances when named as a favorite of at least -146 on the moneyline.
• The Mariners' games have gone over the total in 81 of their 155 opportunities.
• The Mariners have posted a record of 56-99-0 against the spread this season.
• The Astros have won 50% of the games this season they were the underdog on the moneyline (41-41).
• Houston is 9-16 (winning just 36% of its games) when playing as a moneyline underdog of +124 or longer.
• The Astros have played in 157 games with a set over/under, and have combined with opponents to go over the total 76 times (76-74-7).
• The Astros have covered 49.7% of their games this season, going 78-79-0 against the spread.

Mariners Player Leaders

• Randy Arozarena leads Seattle OPS (.859) this season. He has a .279 batting average, an on-base percentage of .379, and a slugging percentage of .480.
• Among qualified hitters in the majors, his batting average ranks 26th, his on-base percentage ranks 10th, and he is 27th in slugging.
• Josh Naylor has hit 10 homers this season while driving in 54 runs. He's batting .266 this season and slugging .356 with an on-base percentage of .321.
• Among all qualifying hitters, he ranks 47th in batting average, 87th in on-base percentage and 125th in slugging percentage.
• Julio Rodriguez has collected 142 base hits, an OBP of .306 and a slugging percentage of .397 this season.
• Rodriguez has recorded a hit in three games in a row. In his last five games he is hitting .368 with two doubles and a walk.
• Cole Young is batting .246 with a .308 OBP and 65 RBI for Seattle this season.

Astros Player Leaders

• Yordan Alvarez has accumulated a team-high OBP (.431) and slugging percentage (.601), while pacing the Astros in hits (172, while batting .314).
• Including all the qualified hitters in the big leagues, his batting average ranks first, his on-base percentage is first, and he is first in slugging.
• Alvarez brings a seven-game hitting streak into this game. In his last 10 outings he is hitting .364 with three doubles, three home runs, seven walks and seven RBIs.
• Isaac Paredes is hitting .262 with 26 doubles, a triple, 23 home runs and 68 walks. He's slugging .440 with an on-base percentage of .360.
• Including all qualified hitters, he ranks 58th in batting average, 29th in on-base percentage and 53rd in slugging percentage.
• Christian Walker is batting .221 with 25 doubles, a triple, 26 home runs and 48 walks.
• Jose Altuve is batting .250 with 24 doubles, two triples, 16 home runs and 40 walks.

Mariners vs Astros Head to Head

• 9/22/2026: 7-0 HOU (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 8/16/2026: 3-2 SEA (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +114)
• 8/15/2026: 10-5 SEA (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +110)
• 8/14/2026: 10-7 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -122, Underdog Moneyline: +112)
• 5/14/2026: 8-3 SEA (Favorite: Mariners, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/13/2026: 4-3 HOU (Favorite: Mariners, Spread: -1.5, Total: 9, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 5/12/2026: 10-2 SEA (Favorite: Mariners, Spread: -1.5, Total: 8.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 5/11/2026: 3-1 SEA (Favorite: Mariners, Spread: -1.5, Total: 8.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 4/13/2026: 6-2 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 4/12/2026: 6-1 SEA (Favorite: Mariners, Spread: -1.5, Total: 7.5, Favorite Moneyline: -190, Underdog Moneyline: +160)

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