Louisville vs Virginia Tech Basketball Prediction, Odds, Picks, Best Bets for February 25

The Louisville Cardinals (21-6, 14-2 ACC) aim to continue a three-game road winning streak when they visit the Virginia Tech Hokies (12-15, 7-9 ACC) on February 25, 2025.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Louisville vs. Virginia Tech Game Info and Odds

• Game day: Tuesday, February 25, 2025
• Game time: 9:00 PM ET
• TV channel: ACC Network
• Location: Blacksburg, Virginia
• Arena: Cassell Coliseum

Louisville vs. Virginia Tech Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Louisville win (86.1%)

Read the betting trends and insights below before placing a wager on Tuesday's Louisville-Virginia Tech spread (Louisville -10.5) or total (146.5 points).

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Louisville vs. Virginia Tech: ATS Betting Stats and Trends

• Louisville has compiled a 16-11-0 record against the spread this season.
• Virginia Tech has put together a 12-15-0 record against the spread this season.
• Louisville covers the spread when it is a 10.5-point favorite or more 33.3% of the time. That's less often than Virginia Tech covers as an underdog of 10.5 or more (66.7%).
• The Cardinals sport a worse record against the spread when playing at home (5-9-0) than they do on the road (9-1-0).
• In 2024-25 against the spread, the Hokies have a lower winning percentage at home (.429, 6-8-0 record) than away (.667, 6-3-0).
• Louisville has 11 wins against the spread in 16 conference games this year.
• Virginia Tech's ACC record against the spread is 10-6-0.

Louisville vs. Virginia Tech: Moneyline Betting Stats

• Louisville has been chosen as the moneyline favorite in 21 games this year and has walked away with the win 17 times (81%) in those games.
• The Cardinals have not lost in nine games this year when favored by -529 or better on the moneyline.
• Virginia Tech has put together a 7-12 record in games it was listed as the moneyline underdog (winning 36.8% of those games).
• The Hokies are 1-2 (winning just 33.3% of their games) when playing as a moneyline underdog of +390 or longer.
• The moneyline set for this matchup implies Louisville has a 84.1% chance of coming away with a victory in the contest.

Louisville vs. Virginia Tech Head-to-Head Comparison

• Louisville has a +282 scoring differential, topping opponents by 10.5 points per game. It is putting up 79.9 points per game to rank 48th in college basketball and is allowing 69.4 per contest to rank 100th in college basketball.
• Chucky Hepburn's team-leading 15.6 points per game ranks 214th in the country.
• Virginia Tech is being outscored by 2.6 points per game, with a -70 scoring differential overall. It puts up 69.1 points per game (296th in college basketball), and gives up 71.7 per contest (180th in college basketball).
• Toibu Lawal is ranked 533rd in the country with a team-high 12.9 points per game.
• The Cardinals win the rebound battle by six boards on average. They record 35.5 rebounds per game, which ranks 31st in college basketball, while their opponents grab 29.5 per contest.
• J'Vonne Hadley averages 7.3 rebounds per game (ranking 132nd in college basketball) to lead the Cardinals.
• The Hokies win the rebound battle by 1.9 boards on average. They collect 30.6 rebounds per game, 269th in college basketball, while their opponents grab 28.7.
• Lawal is 153rd in the nation with 7.1 rebounds per game, leading the Hokies.
• Louisville averages 102.1 points per 100 possessions on offense (45th in college basketball), and allows 88.7 points per 100 possessions (70th in college basketball).
• The Hokies rank 245th in college basketball with 93.7 points scored per 100 possessions, and 290th defensively with 97.2 points conceded per 100 possessions.

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