Louisville vs USC Holiday Bowl Odds, Predictions, Spread, TV Channel, Kickoff Time & Best Bets

The college football schedule on Wednesday includes the Louisville Cardinals taking on the USC Trojans.

We've got you covered, in terms of the most important info regarding NCAA football betting lines, before you make your wager on FanDuel Sportsbook.

Louisville vs USC Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Louisville: (-220) | USC: (+180)
• Spread: Louisville: -6.5 (-105) | USC: +6.5 (-115)
• Total: 57.5 -- Over: (-112) | Under: (-108)

Louisville vs USC Betting Trends

• Louisville is 6-7-0 against the spread this season.
• For the season, Louisville is 4-5 as 6.5-point or better favorites.
• This season, six of Louisville's 13 games have hit the over.
• USC's record against the spread in 2023 is 3-9-0.
• USC has covered every time (1-0) as a 6.5-point or greater underdog this season.
• USC has seen nine of its 12 games hit the over.

Louisville vs USC Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (70.3%)

Louisville vs USC Point Spread

USC is listed as an underdog by 6.5 points (-115 odds), and Louisville, the favorite, is -105 to cover.

Louisville vs USC Over/Under

A combined point total of 57.5 has been set for Louisville-USC on December 27, with the over at -112 and the under at -108.

Louisville vs USC Moneyline

Louisville is a -220 favorite on the moneyline, while USC is a +180 underdog.

Louisville vs. USC Points Insights

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Check out even more in-depth Louisville vs. USC analysis on FanDuel Research.