Louisville vs Pittsburgh Basketball Prediction, Odds, Picks, Best Bets for March 1

The Louisville Cardinals (22-6, 15-2 ACC) aim to continue an eight-game home winning streak when they host the Pittsburgh Panthers (16-12, 7-10 ACC) on March 1, 2025.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Louisville vs. Pittsburgh Game Info and Odds

• Game day: Saturday, March 1, 2025
• Game time: 6 p.m. ET
• TV channel: ESPN2
• Location: Louisville, Kentucky
• Arena: KFC Yum! Center

Louisville vs. Pittsburgh Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Louisville win (79.5%)

Before placing a bet on Saturday's Louisville-Pittsburgh spread (Louisville -10.5) or total (150.5 points), check out the betting trends and insights below.

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Louisville vs. Pittsburgh: ATS Betting Stats and Trends

• Louisville has compiled a 16-12-0 record against the spread this season.
• Pittsburgh has put together a 14-14-0 record against the spread this year.
• Louisville covers the spread when it is a 10.5-point favorite or more 30% of the time. That's more often than Pittsburgh covers as an underdog of 10.5 or more (never covered this season).
• The Cardinals have a worse record against the spread in home games (5-9-0) than they do in road games (9-2-0).
• The Panthers' winning percentage against the spread at home is .625 (10-6-0). On the road, it is .300 (3-7-0).
• Louisville is 11-6-0 against the spread in conference action this season.
• Pittsburgh has five wins against the spread in 17 ACC games this season.

Louisville vs. Pittsburgh: Moneyline Betting Stats

• Louisville has won in 18, or 81.8%, of the 22 contests it has been named as the moneyline favorite in this year.
• The Cardinals have not lost in nine games this year when favored by -599 or better on the moneyline.
• Pittsburgh has won 16.7% of the games this season it was the moneyline underdog (1-5).
• The Panthers have played as a moneyline underdog of +430 or longer in just one game this season, which they lost.
• The moneyline set for this matchup implies Louisville has a 85.7% chance of walking away with the win.

Louisville vs. Pittsburgh Head-to-Head Comparison

• Louisville's +287 scoring differential (outscoring opponents by 10.2 points per game) is a result of scoring 79.5 points per game (51st in college basketball) while giving up 69.3 per contest (96th in college basketball).
• Chucky Hepburn's 15.6 points per game lead Louisville and are 208th in college basketball.
• Pittsburgh is outscoring opponents by 5.5 points per game, with a +155 scoring differential overall. It puts up 76.8 points per game (102nd in college basketball) and allows 71.3 per outing (163rd in college basketball).
• Pittsburgh's leading scorer, Jaland Lowe, ranks 132nd in the nation, scoring 16.7 points per game.
• The Cardinals come out on top in the rebound battle by an average of 5.6 boards. They are pulling down 35.2 rebounds per game (34th in college basketball) compared to their opponents' 29.6 per contest.
• J'Vonne Hadley's 7.4 rebounds per game lead the Cardinals and rank 117th in college basketball play.
• The 30.5 rebounds per game the Panthers accumulate rank 272nd in the country. Their opponents record 30.6.
• Ishmael Leggett's 5.8 rebounds per game lead the Panthers and rank 363rd in college basketball.
• Louisville's 101.6 points per 100 possessions on offense rank 49th in college basketball, and the 88.5 points it allows per 100 possessions rank 66th in college basketball.
• The Panthers rank 49th in college basketball with 101.6 points scored per 100 possessions, and 208th defensively with 94.3 points conceded per 100 possessions.

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