Louisville vs James Madison Prediction, Odds, Picks, Best Bets for Week 2 2025

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The college football schedule on Friday includes the Louisville Cardinals facing the James Madison Dukes.

Before you make your wager on FanDuel Sportsbook, we've got you covered with all the latest NCAA football betting insights.

Louisville vs James Madison Odds & Spread

All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
Moneyline: Louisville: (-581) | James Madison: (+420)
Spread: Louisville: -13.5 (-105) | James Madison: +13.5 (-115)
Total: 55.5 -- Over: (-106) | Under: (-114)

Louisville hasn't won a game against the spread this year.
Louisville has no wins ATS (0-1) as a 13.5-point favorite or greater this season.
One of Louisville's one games this season has gone over the point total.
James Madison has one win against the spread this season.
One James Madison game (out of one) has gone over the point total this season.

All college football win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (81.5%)

Louisville is favored by 13.5 points (-105 to cover) in this matchup. James Madison, the underdog, is -115.

An over/under of 55.5 has been set for Louisville-James Madison on Sept. 5, with the over being -106 and the under -114.

Louisville is the favorite, -581 on the moneyline, while James Madison is a +420 underdog.

The Cardinals had an average implied point total of 32.4 last season, which is 2.6 points lower than their implied total in Friday's game (35).
The average implied point total last season for the Dukes (33.3) is 12.3 more points than the team's implied total in this matchup (21).

Check out even more in-depth Louisville vs. James Madison analysis on FanDuel Research.

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