Louisville vs Florida State Basketball Prediction, Odds, Picks, Best Bets for February 22

The Louisville Cardinals (20-6, 13-2 ACC) will try to build on a four-game winning streak when they host the Florida State Seminoles (16-10, 7-8 ACC) on February 22, 2025 at KFC Yum! Center.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Louisville vs. Florida State Game Info and Odds

• Game day: Saturday, February 22, 2025
• Game time: 12:00 PM ET
• TV channel: The CW
• Location: Louisville, Kentucky
• Arena: KFC Yum! Center

Louisville vs. Florida State Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Louisville win (85.1%)

If you plan to place a wager on Louisville-Florida State matchup (in which Louisville is a 13.5-point favorite and the total has been set at 154.5 points), keep reading for a few betting insights and trends for Saturday's game.

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Louisville vs. Florida State: ATS Betting Stats and Trends

• Louisville is 16-10-0 ATS this season.
• Florida State has compiled a 14-12-0 record against the spread this season.
• The Cardinals have done a better job covering the spread on the road (9-1-0) than they have at home (5-8-0).
• This year, the Seminoles are 9-5-0 at home against the spread (.643 winning percentage). On the road, they are 2-6-0 ATS (.250).
• Louisville has covered the spread 11 times in 15 conference games.
• Against the spread in ACC action, Florida State is 6-9-0 this year.

Louisville vs. Florida State: Moneyline Betting Stats

• Louisville has won in 16, or 80%, of the 20 contests it has been named as the moneyline favorite in this year.
• The Cardinals have not lost in seven games this year when favored by -1205 or better on the moneyline.
• Florida State has gone 3-6 in games it was the underdog on the moneyline (winning 33.3% of those games).
• The Seminoles have not yet played a game with moneyline odds of +720 or longer.
• Louisville has an implied victory probability of 92.3% according to the moneyline set by oddsmakers for this matchup.

Louisville vs. Florida State Head-to-Head Comparison

• Louisville has a +274 scoring differential, topping opponents by 10.5 points per game. It is putting up 79.5 points per game to rank 53rd in college basketball and is allowing 69 per outing to rank 94th in college basketball.
• Louisville's leading scorer, Chucky Hepburn, is 258th in the country putting up 15 points per game.
• Florida State puts up 75.3 points per game (141st in college basketball) while allowing 70.7 per outing (142nd in college basketball). It has a +118 scoring differential and outscores opponents by 4.6 points per game.
• Jamir Watkins leads Florida State, scoring 17.9 points per game (80th in college basketball).
• The Cardinals are 26th in the nation at 35.7 rebounds per game. That's 6.0 more than the 29.7 their opponents average.
• J'Vonne Hadley is 146th in college basketball action with 7.2 rebounds per game to lead the Cardinals.
• The Seminoles rank 182nd in college basketball at 32 rebounds per game. That's similar to the 31.6 their opponents average.
• Malique Ewin tops the Seminoles with eight rebounds per game (64th in college basketball).
• Louisville ranks 48th in college basketball by averaging 101.7 points per 100 possessions on offense, and defensively is 65th in college basketball, allowing 88.2 points per 100 possessions.
• The Seminoles' 94.1 points per 100 possessions on offense rank 228th in college basketball, and the 88.4 points they allow per 100 possessions rank 70th in college basketball.

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