Louisville vs Florida State Basketball Prediction, Odds, Picks, Best Bets for February 22

The Louisville Cardinals (20-6, 13-2 ACC) aim to continue a four-game win streak when they host the Florida State Seminoles (16-10, 7-8 ACC) on February 22, 2025 at KFC Yum! Center.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Louisville vs. Florida State Game Info and Odds

• Game day: Saturday, February 22, 2025
• Game time: 12:00 PM ET
• TV channel: The CW
• Location: Louisville, Kentucky
• Arena: KFC Yum! Center

Louisville vs. Florida State Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Louisville win (85%)

Read the betting trends and insights below before placing a wager on Saturday's Louisville-Florida State spread (Louisville -13.5) or over/under (152.5 points).

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Louisville vs. Florida State: ATS Betting Stats and Trends

• Louisville is 16-10-0 ATS this season.
• Florida State is 14-12-0 ATS this season.
• Against the spread, the Cardinals have fared worse at home, covering five times in 13 home games, and nine times in 10 road games.
• In 2024-25 against the spread, the Seminoles have a better winning percentage at home (.643, 9-5-0 record) than away (.250, 2-6-0).
• Louisville is 11-4-0 against the spread in conference games this year.
• Florida State is 6-9-0 against the spread in ACC play this season.

Louisville vs. Florida State: Moneyline Betting Stats

• Louisville has won in 16, or 80%, of the 20 contests it has been named as the moneyline favorite in this year.
• The Cardinals have yet to lose in seven games when named as moneyline favorite of -1053 or better.
• Florida State has been the underdog on the moneyline nine total times this season. Florida State has gone 3-6 in those games.
• The Seminoles have never played a game this season with moneyline odds of +660 or longer.
• The moneyline set for this matchup implies Louisville has a 91.3% chance of walking away with the win.

Louisville vs. Florida State Head-to-Head Comparison

• Louisville averages 79.5 points per game (53rd in college basketball) while giving up 69.0 per outing (94th in college basketball). It has a +274 scoring differential overall and outscores opponents by 10.5 points per game.
• Chucky Hepburn's team-leading 15.0 points per game ranks 258th in the country.
• Florida State puts up 75.3 points per game (141st in college basketball) while giving up 70.7 per contest (142nd in college basketball). It has a +118 scoring differential and outscores opponents by 4.6 points per game.
• Florida State's leading scorer, Jamir Watkins, ranks 80th in the country, scoring 17.9 points per game.
• The Cardinals pull down 35.7 rebounds per game (26th in college basketball) while allowing 29.7 per outing to their opponents. They outrebound opponents by 6.0 boards per game.
• J'Vonne Hadley is 146th in college basketball play with 7.2 rebounds per game to lead the Cardinals.
• The Seminoles are 182nd in the country at 32.0 rebounds per game. That's similar to the 31.6 their opponents average.
• Malique Ewin averages 8.0 rebounds per game (64th in college basketball) to lead the Seminoles.
• Louisville ranks 48th in college basketball by averaging 101.7 points per 100 possessions on offense, and defensively is 65th in college basketball, allowing 88.2 points per 100 possessions.
• The Seminoles average 94.1 points per 100 possessions on offense (228th in college basketball), and allow 88.4 points per 100 possessions (70th in college basketball).

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