Louisville vs Duke Prediction, Odds, & Betting Trends for College Football Week 9 Game

Saturday's slate in college football includes a matchup between the Louisville Cardinals and the Duke Blue Devils.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA football odds and spreads you need to know.

Louisville vs Duke Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Louisville: (-235) | Duke: (+190)
• Spread: Louisville: -6.5 (-102) | Duke: +6.5 (-120)
• Total: 45.5 -- Over: (-110) | Under: (-110)

Louisville vs Duke Betting Trends

• Louisville is 3-4-0 against the spread this season.
• Louisville has two wins ATS (2-3) as a 6.5-point or higher favorite in 2023.
• There have been three Louisville games (of seven) that hit the over this year.
• Against the spread, Duke is 4-2-0 this year.
• Duke has one win ATS (1-1) as a 6.5-point underdog or greater this year.
• Duke has seen three of its six games hit the over.

Louisville vs Duke Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (56.2%)

Louisville vs Duke Point Spread

Duke is the underdog by 6.5 points against Louisville. Duke is -102 to cover the spread, and Louisville is -120.

Louisville vs Duke Over/Under

A total of 45.5 points has been set for the Louisville-Duke game on October 28, with the over available at -110 and the under at -110.

Louisville vs Duke Moneyline

Duke is a +190 underdog on the moneyline, while Louisville is a -235 favorite.

Louisville vs. Duke Points Insights

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Check out even more in-depth Louisville vs. Duke analysis on FanDuel Research.