Louisville vs Creighton Basketball Prediction, Odds, Picks, Best Bets for NCAA Tournament First Round

The No. 8 seed Louisville Cardinals (27-7) and the No. 9 seed Creighton Bluejays (24-10) will meet in the first round of the NCAA Tournament on Thursday at 12:15 p.m. ET. The contest airs on CBS.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Louisville vs. Creighton Game Info and Odds

• Game day: Thursday, March 20, 2025
• Game time: 12:15 p.m. ET
• TV channel: CBS
• Location: Lexington, Kentucky
• Arena: Rupp Arena

Louisville vs. Creighton Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Louisville win (61.1%)

To help you make an informed wager on Louisville-Creighton matchup (in which Louisville is a 2.5-point favorite and the over/under has been set at 144.5 points), below are a few betting insights and trends for Thursday's game.

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Louisville vs. Creighton: ATS Betting Stats and Trends

• Louisville has won 20 games against the spread this season, while failing to cover 14 times.
• Creighton has compiled a 21-13-0 record against the spread this season.
• When the spread is set as 2.5 or more this season, Louisville (13-11) covers a lower percentage of those games when it is the favorite (54.2%) than Creighton (6-2) does as the underdog (75%).
• The Cardinals sport a worse record against the spread at home (8-9-0) than they do on the road (9-2-0).
• Against the spread, the Bluejays have had better results away (9-2-0) than at home (11-6-0).

Louisville vs. Creighton: Moneyline Betting Stats

• Louisville has been victorious in 22, or 84.6%, of the 26 contests it has been chosen as moneyline favorites in this season.
• This year, the Cardinals have won 21 of 23 games when listed as at least -154 or better on the moneyline.
• Creighton has put together a 4-6 record in games it was the underdog on the moneyline (winning 40% of those games).
• The Bluejays have a 3-5 record (winning just 37.5% of their games) when playing as a moneyline underdog of +128 or longer.
• Louisville has an implied victory probability of 60.6% according to the moneyline set by oddsmakers for this matchup.

Louisville vs. Creighton Head-to-Head Comparison

• Louisville has a +329 scoring differential, topping opponents by 9.7 points per game. It is putting up 78.6 points per game to rank 68th in college basketball and is giving up 68.9 per outing to rank 83rd in college basketball.
• Louisville's leading scorer, Terrence Edwards, is 149th in the nation averaging 16.6 points per game.
• Creighton has a +194 scoring differential, topping opponents by 5.7 points per game. It is putting up 75.2 points per game, 137th in college basketball, and is allowing 69.5 per outing to rank 97th in college basketball.
• Creighton's leading scorer, Ryan Kalkbrenner, is 31st in the nation, averaging 19.4 points per game.
• The Cardinals win the rebound battle by 4.7 boards on average. They collect 34.8 rebounds per game, which ranks 41st in college basketball, while their opponents grab 30.1 per outing.
• J'Vonne Hadley is 129th in college basketball play with 7.3 rebounds per game to lead the Cardinals.
• The 34.7 rebounds per game the Bluejays accumulate rank 47th in the nation, 3.6 more than the 31.1 their opponents grab.
• Kalkbrenner averages 8.8 rebounds per game (40th in college basketball) to lead the Bluejays.
• Louisville ranks 58th in college basketball with 100.9 points scored per 100 possessions, and 59th in college basketball defensively with 88.5 points conceded per 100 possessions.
• The Bluejays rank 99th in college basketball averaging 98.8 points per 100 possessions on offense, and defensively are 121st, allowing 91.3 points per 100 possessions.

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