Louisville vs Creighton Basketball Prediction, Odds, Picks, Best Bets for NCAA Tournament First Round

The No. 8 seed Louisville Cardinals (27-7) will aim to beat the No. 9 seed Creighton Bluejays (24-10) in the first round of the NCAA Tournament on Thursday at Rupp Arena. This contest tips off at 12:15 p.m. ET.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Louisville vs. Creighton Game Info and Odds

• Game day: Thursday, March 20, 2025
• Game time: 12:15 p.m. ET
• TV channel: CBS
• Location: Lexington, Kentucky
• Arena: Rupp Arena

Louisville vs. Creighton Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Louisville win (61.2%)

Louisville is a 2.5-point favorite against Creighton on Thursday and the total is set at 145.5 points. Here's some betting insights and trends before you decide to wager on the matchup.

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Louisville vs. Creighton: ATS Betting Stats and Trends

• Louisville has covered 20 times in 34 chances against the spread this season.
• Creighton has compiled a 21-13-0 record against the spread this year.
• When the spread is set as 2.5 or more this season, Louisville (13-11) covers a lower percentage of those games when it is the favorite (54.2%) than Creighton (6-2) does as the underdog (75%).
• The Cardinals have covered the spread in a lower percentage of their home games than away games. They have covered eight times in 17 games when playing at home, and they've covered nine times in 11 games when playing on the road.
• Against the spread, the Bluejays have had better results on the road (9-2-0) than at home (11-6-0).

Louisville vs. Creighton: Moneyline Betting Stats

• Louisville has been the moneyline favorite in 26 games this season and has come away with the win 22 times (84.6%) in those contests.
• This season, the Cardinals have come away with a win 21 times in 24 chances when named as a favorite of at least -148 or better on the moneyline.
• Creighton has been the underdog on the moneyline 10 total times this season. Creighton has gone 4-6 in those games.
• The Bluejays have a record of 3-5 in games they have played as a moneyline underdog with odds of +126 or longer (37.5%).
• Louisville has an implied victory probability of 59.7% according to the moneyline set for this matchup.

Louisville vs. Creighton Head-to-Head Comparison

• Louisville outscores opponents by 9.7 points per game (scoring 78.6 per game to rank 68th in college basketball while allowing 68.9 per contest to rank 83rd in college basketball) and has a +329 scoring differential overall.
• Terrence Edwards leads Louisville, recording 16.6 points per game (149th in the country).
• Creighton puts up 75.2 points per game (137th in college basketball) while allowing 69.5 per outing (97th in college basketball). It has a +194 scoring differential and outscores opponents by 5.7 points per game.
• Ryan Kalkbrenner's 19.4 points per game leads Creighton and ranks 31st in college basketball.
• The Cardinals win the rebound battle by 4.7 boards on average. They collect 34.8 rebounds per game, which ranks 42nd in college basketball, while their opponents pull down 30.1 per outing.
• J'Vonne Hadley leads the team with 7.3 rebounds per game (129th in college basketball action).
• The Bluejays average 34.7 rebounds per game (47th in college basketball) while allowing 31.1 per contest to opponents. They outrebound opponents by 3.6 boards per game.
• Kalkbrenner averages 8.8 rebounds per game (40th in college basketball) to lead the Bluejays.
• Louisville puts up 100.9 points per 100 possessions (57th in college basketball), while allowing 88.5 points per 100 possessions (59th in college basketball).
• The Bluejays record 98.8 points per 100 possessions (99th in college basketball), while allowing 91.3 points per 100 possessions (121st in college basketball).

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