Lions vs Cardinals Prediction, Odds, Picks, Best Bets for NFL Week 5

The Sunday schedule in the NFL includes a matchup between the Detroit Lions and the Arizona Cardinals.

Before you make your wager on FanDuel Sportsbook, we've got you covered, in terms of the most important information about today's NFL betting odds.

Lions vs Cardinals Prediction & Pick

All NFL win probability predictions and picks are according to numberFire.
Prediction: Lions win (65.7%)

Lions vs Cardinals Point Spread

The Lions are 4.5-point favorites against the Cardinals. The Lions are -112 to cover the spread, while the Cardinals are -108 to cover as a 4.5-point underdog.

Lions vs Cardinals Over/Under

An over/under of 53.5 has been set for Lions-Cardinals on Oct. 11, with the over being -115 and the under -105.

Lions vs Cardinals Moneyline

Looking at the moneyline for Cardinals-Lions, Arizona is the underdog at +198, and Detroit is -240 playing on the road.

Lions vs Cardinals Betting Trends

• Detroit has one win against the spread this year.
• The Lions have one win ATS (1-1) as a 4.5-point favorite or greater this year.
• The Lions and their opponent have hit the over in every game this season.
• The Cardinals have posted two wins against the spread this season.
• Arizona has won twice ATS (2-1) as a 4.5-point underdog or more this year.
• Two of the Cardinals' four games in 2026 have gone over the point total.

Check out even more in-depth Lions vs. Cardinals analysis on FanDuel Research.

Lions vs Cardinals Odds & Spread

• All NFL odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: DET: (-240) | ARI: (+198)
• Spread: DET: -4.5 (-112) | ARI: +4.5 (-108)
• Total: 53.5 -- Over: (-115) | Under: (-105)

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