Lions vs Bills Prediction, Odds, Picks, Best Bets for NFL Week 15

The Detroit Lions are among the NFL squads playing on Sunday, versus the Buffalo Bills.

We've got you covered, in terms of the most important information regarding NFL betting lines, before you make your wager on FanDuel Sportsbook.

Lions vs Bills Prediction & Pick

All NFL win probability predictions and picks are according to numberFire.
Prediction: Lions win (62.6%)

Lions vs Bills Point Spread

The Lions are 2.5-point favorites against the Bills. The Lions are -110 to cover the spread, while the Bills are -110 to cover as a 2.5-point underdog.

Lions vs Bills Over/Under

A combined point total of 54.5 has been set for Lions-Bills on Dec. 15, with the over at -110 and the under at -110.

Lions vs Bills Moneyline

Buffalo is the underdog, +122 on the moneyline, while Detroit is a -144 favorite at home.

Lions vs Bills Betting Trends

• Against the spread, Detroit is 9-4-0 this season.
• As 2.5-point favorites or more, the Lions are 8-4 against the spread.
• Out of 13 Lions games so far this year, seven have gone over the total.
• Against the spread, the Bills are 8-5-0 this season.
• Buffalo has one win ATS (1-1) as a 2.5-point underdog or greater this year.
• The Bills have seen nine of their 13 games go over the point total.

Lions vs Bills Odds & Spread

• All NFL odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: DET: (-144) | BUF: (+122)
• Spread: DET: -2.5 (-110) | BUF: +2.5 (-110)
• Total: 54.5 -- Over: (-110) | Under: (-110)

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