Iowa State vs Southern Miss College Basketball Prediction, Odds, Picks, Best Bets for Nov. 6

The Iowa State Cyclones (0-1) go up against the Southern Miss Golden Eagles (1-0) on November 6, 2026. The matchup airs on ESPN+.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Iowa State vs. Southern Miss Game Info and Odds

• Game day: Friday, November 6, 2026
• Game time: 8 p.m. ET
• TV channel: ESPN+
• Location: Ames, Iowa
• Arena: James H. Hilton Coliseum

Take a look at some betting insights for Iowa State (-30.5) versus Southern Miss on Friday. The total has been set at 150.5 points for this game.

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!

Iowa State vs. Southern Miss: ATS Betting Stats and Trends

• Iowa State covered 22 times in 37 games with a spread last season.
• Southern Miss put together a 17-16-0 record against the spread last year.
• In home games last season, the Cyclones sported a better record against the spread (9-8-0) compared to their ATS record on the road (5-5-0).
• The Golden Eagles were better against the spread on the road (7-8-0) than at home (5-6-0) last year.

Iowa State vs. Southern Miss Head-to-Head Comparison

• Iowa State was 48th in college basketball in points scored (82 per game) and 13th-best in points conceded (65.6) last year.
• With 31.9 rebounds per game and 28.8 rebounds allowed, Iowa State was 187th and 47th in the country, respectively, last season.
• Last season Iowa State was 19th-best in the nation in assists with 17.4 per game.
• Last year, Iowa State was 73rd in the country in turnovers committed (9.9 per game) and fifth-best in turnovers forced (14.6).
• With 74.7 points per game on offense, Southern Miss was 209th in the nation last season. At the other end of the court, it gave up 73.9 points per contest, which ranked 180th in college basketball.
• Southern Miss pulled down 33 rebounds per game (116th-ranked in college basketball) last season, while allowing 30.3 rebounds per contest (121st-ranked).
• Southern Miss didn't produce many assists last season, ranking 22nd-worst in college basketball with 11.5 assists per game.
• Southern Miss was 294th in the nation with 12.1 turnovers per game last year. Meanwhile, it ranked 111th with 11.8 forced turnovers per game.

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!