Iowa State vs Ole Miss Basketball Prediction, Odds, Picks, Best Bets for NCAA Tournament Second Round

The No. 3 seed Iowa State Cyclones (25-9) and the No. 6 seed Ole Miss Rebels (23-11) will square off in the NCAA Tournament with a trip to the Sweet 16 of the South Region bracket up for grabs on Sunday at Fiserv Forum, starting at 7:45 p.m. ET.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Iowa State vs. Ole Miss Game Info and Odds

• Game day: Sunday, March 23, 2025
• Game time: 7:45 p.m. ET
• TV channel: truTV
• Location: Milwaukee, Wisconsin
• Arena: Fiserv Forum

Iowa State vs. Ole Miss Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Iowa State win (68.5%)

If you plan to place a wager on Iowa State-Ole Miss matchup (in which Iowa State is a 5.5-point favorite and the over/under is set at 144.5 points), below are some betting insights and trends for Sunday's game.

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Iowa State vs. Ole Miss: ATS Betting Stats and Trends

• Iowa State is 20-14-0 ATS this season.
• Ole Miss is 17-17-0 ATS this year.
• When the spread is set as 5.5 or more this season, Iowa State (17-11) covers a higher percentage of those games when it is the favorite (60.7%) than Ole Miss (3-3) does as the underdog (50%).
• Against the spread, the Cyclones have fared worse at home, covering nine times in 17 home games, and seven times in 11 road games.
• In 2024-25 against the spread, the Rebels have a better winning percentage at home (.438, 7-9-0 record) than away (.364, 4-7-0).

Iowa State vs. Ole Miss: Moneyline Betting Stats

• Iowa State has won in 19, or 79.2%, of the 24 contests it has been named as the moneyline favorite in this year.
• This year, the Cyclones have won 18 of 22 games when listed as at least -240 or better on the moneyline.
• Ole Miss has been the underdog on the moneyline 15 total times this season. Ole Miss has finished 6-9 in those games.
• In games they have played as a moneyline underdog with odds of +198 or longer, the Rebels have gone 1-3 (25%).
• The moneyline set for this matchup implies Iowa State has a 70.6% chance of coming away with a victory in the contest.

Iowa State vs. Ole Miss Head-to-Head Comparison

• Iowa State averages 80.4 points per game (34th in college basketball) while allowing 67.7 per outing (54th in college basketball). It has a +433 scoring differential overall and outscores opponents by 12.7 points per game.
• Curtis Jones' team-leading 17.1 points per game ranks 106th in college basketball.
• Ole Miss has a +187 scoring differential, topping opponents by 5.5 points per game. It is putting up 77 points per game, 90th in college basketball, and is allowing 71.5 per outing to rank 164th in college basketball.
• Sean Pedulla paces Ole Miss, scoring 15 points per game (260th in college basketball).
• The Cyclones rank 142nd in college basketball at 32.7 rebounds per game. That's 4.4 more than the 28.3 their opponents average.
• Joshua Jefferson leads the team with 7.4 rebounds per game (120th in college basketball action).
• The Rebels lose the rebound battle by 3.5 boards on average. They record 29.9 rebounds per game, 302nd in college basketball, while their opponents grab 33.4.
• Malik Dia averages 5.7 rebounds per game (395th in college basketball) to lead the Rebels.
• Iowa State ranks 35th in college basketball by averaging 102.5 points per 100 possessions on offense, and defensively is 24th in college basketball, allowing 86.3 points per 100 possessions.
• The Rebels put up 99.2 points per 100 possessions (91st in college basketball), while giving up 92.1 points per 100 possessions (140th in college basketball).

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