Iowa State vs Mississippi State College Basketball Prediction, Odds, Picks, Best Bets for Nov. 10

The Iowa State Cyclones (2-0) take the court against the Mississippi State Bulldogs (1-0) on November 10, 2025.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Iowa State vs. Mississippi State Game Info and Odds

• Game day: Monday, November 10, 2025
• Game time: 8 p.m. ET
• TV channel: ESPNU
• Location: Sioux Falls, South Dakota
• Arena: Sanford Pentagon

Iowa State vs. Mississippi State Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Iowa State win (67.6%)

Read the betting insights and trends below before placing a bet on Monday's Iowa State-Mississippi State spread (Iowa State -5.5) or total (150.5 points).

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Iowa State vs. Mississippi State: ATS Betting Stats and Trends

• Iowa State put together a 20-15-0 ATS record last year.
• Mississippi State put together a 15-19-0 ATS record last year.
• Iowa State covered the spread when it was a 5.5-point favorite or more 58.6% of the time last year. That's more often than Mississippi State covered as an underdog by 5.5 or more (never covered last season).
• The Cyclones covered the spread in a lower percentage of their home games than away games last season. They covered nine times in 17 games at home, and they covered seven times in 11 games when playing on the road.
• Last year, the Bulldogs were 6-9-0 at home against the spread (.400 winning percentage). On the road, they were 6-5-0 ATS (.545).

Iowa State vs. Mississippi State: Moneyline Betting Stats

• Iowa State finished with a 19-6 record in games it was favored on the moneyline last season (winning 76% of those games).
• The Cyclones went 14-4 when playing as a moneyline favorite with odds of -260 or shorter (77.8%).
• Last season, Mississippi State won two out of the six games in which it was the underdog.
• Last season, the Bulldogs were at least a +210 underdog on the moneyline three times, losing each of those contests.
• Based on this game's moneyline, Iowa State has an implied win probability of 72.2%.

Iowa State vs. Mississippi State Head-to-Head Comparison

• Last year, Iowa State was 34th in college basketball offensively (80.3 points scored per game) and 61st on defense (68.3 points allowed).
• Iowa State grabbed 32.7 rebounds per game and gave up 28.3 boards last year, ranking 142nd and 31st, respectively, in college basketball.
• Last season Iowa State was ranked 77th in the country in assists with 15 per game.
• In terms of turnovers, Iowa State was 232nd in the country in committing them (11.6 per game) last season. It was 13th-best in forcing them (14.4 per game).
• Mississippi State scored 79.5 points per game (47th-ranked in college basketball) last year, while ceding 74.2 points per contest (245th-ranked).
• Mississippi State ranked 28th in the country with 35.2 boards per game. Meanwhile, it ranked 283rd with 32.8 rebounds allowed per contest.
• Mississippi State ranked 69th in college basketball with 15.2 dimes per contest.
• Mississippi State averaged 10.3 turnovers per game (98th-ranked in college basketball). It forced 12.6 turnovers per contest (67th-ranked).

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