Iowa State vs Lipscomb Basketball Prediction, Odds, Picks, Best Bets for NCAA Tournament First Round

The No. 3 Iowa State Cyclones (24-9) and the No. 14 Lipscomb Bisons (25-9) meet on Friday for a spot in the second round of the NCAA Tournament. The first-round matchup begins at 1:30 p.m. ET.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Iowa State vs. Lipscomb Game Info and Odds

• Game day: Friday, March 21, 2025
• Game time: 1:30 p.m. ET
• TV channel: TNT
• Location: Milwaukee, Wisconsin
• Arena: Fiserv Forum

Iowa State vs. Lipscomb Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Iowa State win (75.5%)

Take a look at these betting insights and trends before you wager on Friday's Iowa State-Lipscomb spread (Iowa State -14.5) or total (142.5 points).

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Iowa State vs. Lipscomb: ATS Betting Stats and Trends

• Iowa State has put together a 19-14-0 record against the spread this season.
• Lipscomb has compiled a 15-16-0 ATS record so far this year.
• Iowa State covers the spread when it is a 14.5-point favorite or more 45.5% of the time. That's more often than Lipscomb covers as an underdog of 14.5 or more (never covered this season).
• In home games, the Cyclones own a worse record against the spread (9-8-0) compared to their ATS record in road games (7-4-0).
• Against the spread, the Bisons have had better results away (8-8-0) than at home (7-8-0).

Iowa State vs. Lipscomb: Moneyline Betting Stats

• Iowa State has been victorious in 18, or 78.3%, of the 23 contests it has been chosen as moneyline favorites in this season.
• This season, the Cyclones have been victorious five times in six chances when named as a favorite of at least -1449 or better on the moneyline.
• Lipscomb has won 33.3% of the games this season it was the moneyline underdog (2-4).
• The Bisons have played as a moneyline underdog of +810 or longer in just two games this season, which they lost both.
• The moneyline set for this matchup implies Iowa State has a 93.5% chance of walking away with the win.

Iowa State vs. Lipscomb Head-to-Head Comparison

• Iowa State's +406 scoring differential (outscoring opponents by 12.3 points per game) is a result of scoring 80.4 points per game (34th in college basketball) while giving up 68.1 per contest (63rd in college basketball).
• Iowa State's leading scorer, Curtis Jones, ranks 106th in the country putting up 17.1 points per game.
• Lipscomb outscores opponents by 12 points per game (posting 79.3 points per game, 51st in college basketball, and giving up 67.3 per contest, 49th in college basketball) and has a +408 scoring differential.
• Jacob Ognacevic leads Lipscomb, recording 20.1 points per game (16th in college basketball).
• The Cyclones rank 142nd in the nation at 32.7 rebounds per game. That's 4.2 more than the 28.5 their opponents average.
• Joshua Jefferson's 7.4 rebounds per game lead the Cyclones and rank 120th in college basketball action.
• The Bisons rank 98th in college basketball at 33.3 rebounds per game. That's 1.9 more than the 31.4 their opponents average.
• Ognacevic averages 8.1 rebounds per game (58th in college basketball) to lead the Bisons.
• Iowa State's 102.2 points per 100 possessions on offense rank 41st in college basketball, and the 86.6 points it allows per 100 possessions rank 26th in college basketball.
• The Bisons record 104.8 points per 100 possessions (17th in college basketball), while giving up 89 points per 100 possessions (66th in college basketball).

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