Iowa State vs Eastern Illinois College Basketball Prediction, Odds, Picks, Best Bets for Dec. 14

The Iowa State Cyclones (10-0) hope to continue an eight-game home winning streak when they host the Eastern Illinois Panthers (2-7) on December 14, 2025.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Iowa State vs. Eastern Illinois Game Info and Odds

• Game day: Sunday, December 14, 2025
• Game time: 1 p.m. ET
• TV channel: ESPN+
• Location: Ames, Iowa
• Arena: James H. Hilton Coliseum

Iowa State vs. Eastern Illinois Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Iowa State win (99.6%)

Before you wager on Sunday's Iowa State-Eastern Illinois spread (Iowa State -40.5) or over/under (143.5 points), see the betting trends and insights below.

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Iowa State vs. Eastern Illinois: ATS Betting Stats and Trends

• Iowa State has compiled a 7-3-0 record against the spread this season.
• Eastern Illinois has compiled a 3-5-0 ATS record so far this year.
• Iowa State covers the spread when it is a 40.5-point favorite or more 100% of the time. That's more often than Eastern Illinois covers as an underdog of 40.5 or more (never covered this season).
• The Cyclones had a worse record against the spread in home games (9-8-0) than they did in road games (7-4-0) last season.
• In 2025-26 against the spread, the Panthers have a lower winning percentage at home (.333, 1-2-0 record) than away (.400, 2-3-0).

Iowa State vs. Eastern Illinois Head-to-Head Comparison

• Iowa State was 34th in the nation in points scored (80.3 per game) and 61st in points conceded (68.3) last year.
• Iowa State was 142nd in the country in rebounds per game (32.7) and 31st in rebounds conceded (28.3) last season.
• Last season Iowa State was ranked 77th in the nation in assists with 15 per game.
• Iowa State was 232nd in the nation in turnovers per game (11.6) and 13th-best in turnovers forced (14.4) last season.
• Eastern Illinois averaged only 66.5 points per game (18th-worst in college basketball) last season, but it played better at the other end, where it gave up 69 points per game (81st-ranked).
• Eastern Illinois grabbed 31.3 rebounds per game (214th-ranked in college basketball) last season, while allowing 33.2 rebounds per contest (300th-ranked).
• Eastern Illinois put up 11.3 assists per game, which ranked them 330th in the nation.
• Eastern Illinois ranked 17th-best in the country by forcing 14.2 turnovers per game. It ranked 232nd in college basketball by committing 11.6 turnovers per contest.

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