Guardians vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 14

Odds updated as of 1:12 a.m.

The Cleveland Guardians versus the Chicago White Sox is on the MLB schedule for Monday.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Guardians vs White Sox Game Info

• Cleveland Guardians (76-74) vs. Chicago White Sox (76-73)
• Date: Monday, September 14, 2026
• Time: 6:40 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CleGuardians.TV and CHSN

Guardians vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-144) | CHW: (+122)
• Spread: CLE: -1.5 (+162) | CHW: +1.5 (-196)
• Total: 7.5 -- Over: (+112) | Under: (-138)

Guardians vs White Sox Probable Starting Pitchers

Probable Pitchers: Gavin Williams (Guardians) - 13-7, 3.78 ERA vs Sean Newcomb (White Sox) - 2-4, 2.77 ERA

The Guardians will give the ball to Gavin Williams (13-7, 3.78 ERA), who is eyeing win No. 14 on the season, and the White Sox will counter with Sean Newcomb (2-4, 2.77 ERA). Williams' team is 14-14-0 against the spread in his starts this season. When Williams starts a game and his team is the favorite on the moneyline, they have a record of 14-9. The White Sox have a 3-2-0 record against the spread in Newcomb's starts. The White Sox have been the moneyline underdog in three of Newcomb's starts this season, and they went 2-1 in those matchups.

Guardians vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (50.6%)

Guardians vs White Sox Moneyline

• Looking at the moneyline for White Sox-Guardians, Chicago is the underdog at +122, and Cleveland is -144 playing at home.

Guardians vs White Sox Spread

• The White Sox are +1.5 on the run line against the Guardians. The White Sox are -196 to cover, and the Guardians are +162.

Guardians vs White Sox Over/Under

• An over/under of 7.5 has been set for Guardians-White Sox on Sept. 14, with the over being +112 and the under -138.

Bet on Cleveland Guardians vs. Chicago White Sox on FanDuel today!

Guardians vs White Sox Betting Trends

• The Guardians have come away with 43 wins in the 84 contests they have been listed as the favorites in this season.
• This year Cleveland has won 18 of 28 games when listed as at least -144 on the moneyline.
• The Guardians and their opponents have gone over in 69 of their 142 games with a total set by sportsbooks this season.
• The Guardians have posted a record of 67-75-0 against the spread this season.
• The White Sox have won 48% of the games this season they were the moneyline underdog (49-53).
• When playing as a moneyline underdog with odds of +122 or longer, Chicago has a 23-27 record (winning 46% of its games).
• The White Sox have combined with opponents to hit the over on the total 80 times this season for an 80-65-1 record against the over/under.
• The White Sox have covered 55.5% of their games this season, going 81-65-0 ATS.

Guardians Player Leaders

• Chase DeLauter has 134 hits, which is best among Cleveland hitters this season, while batting .291 with 45 extra-base hits. He has an on-base percentage of .363 and a slugging percentage of .456.
• He ranks 12th in batting average, 25th in on-base percentage, and 42nd in slugging among all qualifying hitters in baseball.
• Steven Kwan leads the Guardians with an OPS of .721. He has a slash line of .278/.375/.346 this season.
• He is 26th in batting average, 10th in on-base percentage and 130th in slugging among qualifying hitters.
• Kwan heads into this matchup looking to extend his seven-game hit streak. During his last 10 games he is hitting .317 with four doubles, a home run, four walks and three RBIs.
• Jose Ramirez has 98 hits this season and has a slash line of .230/.320/.363.
• Brayan Rocchio is batting .246 with a .306 OBP and 65 RBI for Cleveland this season.

White Sox Player Leaders

• Miguel Vargas has accumulated 135 hits, a team-best for the White Sox. He's batting .247 and slugging .470 with an on-base percentage of .355.
• Including all the qualifying hitters in MLB, his batting average ranks 85th, his on-base percentage ranks 38th, and he is 31st in slugging.
• Vargas hopes to build on a three-game hitting streak in this matchup. In his last five games he is batting .150 with a walk.
• Sam Antonacci has a .366 OBP to pace his team. He has a batting average of .269 while slugging .393.
• Including all qualifying players, his batting average places him 43rd, his on-base percentage ranks 20th, and he is 97th in slugging.
• Chase Meidroth has a .398 slugging percentage, which paces the White Sox.
• Tristan Peters has 31 doubles, four triples, 12 home runs and 34 walks while batting .279.

Guardians vs White Sox Head to Head

• 8/9/2026: 5-3 CHW (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +116)
• 8/8/2026: 6-3 CHW (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +116)
• 8/7/2026: 8-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -138, Underdog Moneyline: +126)
• 7/4/2026: 3-1 CHW (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 7/3/2026: 4-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/2/2026: 6-5 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/24/2026: 4-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/23/2026: 2-1 CHW (Favorite: Guardians, Spread: -1.5, Total: 7, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/22/2026: 6-5 CHW (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/14/2025: 3-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -162, Underdog Moneyline: +136)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!