Guardians vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for April 10

Odds updated as of 12:12 p.m.

The Cleveland Guardians versus the Chicago White Sox is on the MLB schedule for Thursday.

We've got you covered, in terms of the vital information about this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Guardians vs White Sox Game Info

• Cleveland Guardians (5-6) vs. Chicago White Sox (2-9)
• Date: Thursday, April 10, 2025
• Time: 1:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CLEG and CHSN

Guardians vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-245) | CHW: (+200)
• Spread: CLE: -1.5 (-114) | CHW: +1.5 (-105)
• Total: 7 -- Over: (-120) | Under: (-102)

Guardians vs White Sox Probable Starting Pitchers

Probable Pitchers: Gavin Williams (Guardians) - 0-0, 4.50 ERA vs Jonathan Cannon (White Sox) - 0-1, 3.12 ERA

The Guardians will give the nod to Gavin Williams and the White Sox will turn to Jonathan Cannon (0-1, 3.12 ERA). Williams has a record of 1-1-0 ATS in two starts with a spread this season. Williams' team won his only start as a favorite this season. Cannon has started two games with set spreads, and the White Sox went 1-1-0. The White Sox were the underdog on the moneyline for two Cannon starts this season -- they lost both.

Guardians vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (67.7%)

Guardians vs White Sox Moneyline

• Chicago is the underdog, +200 on the moneyline, while Cleveland is a -245 favorite at home.

Guardians vs White Sox Spread

• The White Sox are +1.5 on the run line against the Guardians. The White Sox are -105 to cover, and the Guardians are -114.

Guardians vs White Sox Over/Under

• The over/under for the Guardians versus White Sox contest on April 10 has been set at 7, with -120 odds on the over and -102 odds on the under.

Bet on Cleveland Guardians vs. Chicago White Sox on FanDuel today!

Guardians vs White Sox Betting Trends

• The Guardians have been chosen as favorites in five games this year and have walked away with the win three times (60%) in those games.
• These are the best odds of a victory sportsbooks have given Cleveland this season, with a -245 moneyline set for this game.
• The Guardians and their opponents have gone over the total this season in five of their 11 opportunities.
• The Guardians are 3-8-0 against the spread in their 11 games with a line set by sportsbooks this season.
• The White Sox have gone 2-9 in games they were the underdog on the moneyline (winning 18.2% of those games).
• Chicago has never played a game this season with moneyline odds of +200 or longer.
• The White Sox have combined with opponents to hit the over on the total five times this season for a 5-5-1 record against the over/under.
• The White Sox have a 7-4-0 record ATS this season (covering 63.6% of the time).

Guardians Player Leaders

• Jose Ramirez leads Cleveland in OBP (.400) and total hits (nine) this season. He's batting .281 batting average while slugging .719.
• Among qualified batters in MLB, he is 57th in batting average, 27th in on-base percentage, and sixth in slugging.
• Carlos Santana has hit two homers this season while driving in four runs. He's batting .286 this season and slugging .476 with an on-base percentage of .340.
• Among qualifiers, he ranks 48th in batting average, 72nd in on-base percentage and 55th in slugging percentage.
• Santana enters this game looking to extend his two-game hit streak. In his last five games he is hitting .316 with two home runs, two walks and three RBI.
• Kyle Manzardo has eight hits this season and has a slash line of .222/.333/.556.
• Steven Kwan leads Cleveland with a slugging percentage of .400, fueled by two extra-base hits.

White Sox Player Leaders

• Nick Maton has two home runs and five walks while hitting .167. He's slugging .417 with an on-base percentage of .310.
• Matt Thaiss has a double and seven walks while hitting .211. He's slugging .263 with an on-base percentage of .407.
• Andrew Vaughn has totaled five hits, a team-high for the White Sox.
• Miguel Vargas paces his team with a .289 on-base percentage.

Guardians vs White Sox Head to Head

• 4/9/2025: 3-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 4/8/2025: 1-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 7, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 9/11/2024: 6-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -235, Underdog Moneyline: +194)
• 9/10/2024: 5-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -235, Underdog Moneyline: +194)
• 9/9/2024: 5-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 7/4/2024: 8-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -225, Underdog Moneyline: +188)
• 7/3/2024: 8-2 CHW (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -215, Underdog Moneyline: +180)
• 7/2/2024: 7-6 CLE (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 5/12/2024: 7-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 5/11/2024: 3-1 CHW (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -168, Underdog Moneyline: +142)

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