Guardians vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for ALDS Game 5 on Oct. 10

Odds updated as of 6:11 a.m.

The Cleveland Guardians versus the Chicago White Sox in Game 5 of the ALDS is on the MLB schedule for Saturday.

We've got you covered, in terms of the vital info about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Guardians vs White Sox Game Info

• Cleveland Guardians (85-77) vs. Chicago White Sox (84-78)
• Date: Saturday, October 10, 2026
• Time: 8 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: TBS, truTV, and HBO Max

Guardians vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-138) | CHW: (+118)
• Spread: CLE: -1.5 (+164) | CHW: +1.5 (-200)
• Total: 7.5 -- Over: (+110) | Under: (-134)

Guardians vs White Sox Probable Starting Pitchers

Probable Pitchers: Gavin Williams (Guardians) - 14-8, 3.76 ERA vs Sean Burke (White Sox) - 11-7, 3.34 ERA

The probable starters are Gavin Williams (14-8, 3.76 ERA) for the Guardians and Sean Burke (11-7, 3.34 ERA) for the White Sox. Williams and his team are 14-16-0 ATS this season when he starts. Williams' team is 14-11 this season when he starts and they are the moneyline favorite. The White Sox have a 16-12-0 record against the spread in Burke's starts. The White Sox are 7-9 in Burke's 16 starts this season that they were the underdog on the moneyline.

Guardians vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (51.8%)

Guardians vs White Sox Moneyline

• Looking at the moneyline for Guardians-White Sox, Cleveland is the favorite at -138, and Chicago is +118 playing on the road.

Guardians vs White Sox Spread

• The Guardians are 1.5-run home favorites on the runline against the White Sox. The Guardians are +164 to cover, and the White Sox are -200.

Guardians vs White Sox Over/Under

• The Guardians-White Sox contest on Oct. 10 has been given an over/under of 7.5 runs. The over is set at +110 and the under at -134.

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Guardians vs White Sox Betting Trends

• The Guardians have won in 49, or 52.7%, of the 93 contests they have been named as odds-on favorites in this year.
• Cleveland has a record of 25-15 when favored by -138 or more this year.
• The Guardians and their opponents have gone over the total this season in 77 of their 156 opportunities.
• The Guardians have posted a record of 75-81-0 against the spread this season.
• The White Sox have a 54-56 record in games they were listed as the moneyline underdog (winning 49.1% of those games).
• Chicago is 30-36 (winning 45.5% of its games) when it has played as a moneyline underdog of +118 or longer.
• The White Sox have played in 165 games with a set over/under, and have combined with opponents to go over the total 94 times (94-70-1).
• The White Sox have a 94-71-0 record ATS this season.

Guardians Player Leaders

• Chase DeLauter leads Cleveland with 142 hits, batting .287 this season with 49 extra-base hits. He has an on-base percentage of .363 and a slugging percentage of .457.
• Among qualified hitters in baseball, his batting average ranks 16th, his on-base percentage ranks 24th, and he is 43rd in slugging.
• DeLauter hopes to build on a three-game hitting streak in this matchup. During his last five outings he is hitting .250 with a home run, three walks and three RBIs.
• Steven Kwan has a slash line of .282/.382/.349 this season and a team-best OPS of .731.
• He ranks 21st in batting average, seventh in on-base percentage and 131st in slugging in the major leagues.
• Kwan heads into this matchup looking to extend his three-game hit streak. During his last five outings he is batting .300 with a triple, four walks and two RBIs.
• Jose Ramirez has 111 hits this season and has a slash line of .235/.320/.368.
• Ramirez has logged a hit or more in two straight games. In his last five games he is hitting .200 with a double, a triple, a home run, three walks and five RBIs.
• Brayan Rocchio has been key for Cleveland with 135 hits, an OBP of .313 plus a slugging percentage of .391.

White Sox Player Leaders

• Miguel Vargas is hitting .250 with 31 doubles, a triple, 33 home runs and 101 walks. He's slugging .474 with an on-base percentage of .363.
• He ranks 79th in batting average, 24th in on-base percentage and 30th in slugging percentage among all qualifying hitters in the majors.
• Vargas enters this matchup on a four-game hitting streak. During his last five outings he is batting .267 with a home run, eight walks and an RBI.
• Chase Meidroth is slugging .415 to pace his team. He has a batting average of .276 with an on-base percentage of .350.
• Including all qualified hitters, he is 33rd in batting average, 45th in on-base percentage and 80th in slugging percentage.
• Sam Antonacci has a team-best .370 on-base percentage.
• Munetaka Murakami paces his team with 94 hits.

Guardians vs White Sox Head to Head

• 10/8/2026: 9-5 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -114, Underdog Moneyline: +100)
• 10/7/2026: 9-3 CLE (Favorite: White Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -128, Underdog Moneyline: +112)
• 10/5/2026: 4-3 CHW (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -152, Underdog Moneyline: +136)
• 10/3/2026: 3-0 CHW (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -144, Underdog Moneyline: +128)
• 9/16/2026: 6-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 9/15/2026: 7-6 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 9/14/2026: 7-3 CHW (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 8/9/2026: 5-3 CHW (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +116)
• 8/8/2026: 6-3 CHW (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +116)
• 8/7/2026: 8-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -138, Underdog Moneyline: +126)

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