Guardians vs Twins Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 11

Odds updated as of 2:12 a.m.

MLB action on Friday includes the Cleveland Guardians playing the Minnesota Twins.

All the info you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Guardians vs Twins Game Info

• Cleveland Guardians (74-73) vs. Minnesota Twins (69-77)
• Date: Friday, September 11, 2026
• Time: 8:10 p.m. ET
• Venue: Target Field -- Minneapolis, Minnesota
• Coverage: Twins.TV and CleGuardians.TV

Guardians vs Twins Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-120) | MIN: (+102)
• Spread: CLE: -1.5 (+138) | MIN: +1.5 (-166)
• Total: 7.5 -- Over: (-110) | Under: (-110)

Guardians vs Twins Probable Starting Pitchers

Probable Pitchers: Parker Messick (Guardians) - 11-9, 2.53 ERA vs Taj Bradley (Twins) - 11-6, 3.95 ERA

The Guardians will call on Parker Messick (11-9) against the Twins and Taj Bradley (11-6). Messick's team is 14-14-0 against the spread this season in his starts. Messick's team has a record of 10-12 this season when he starts and they are the favorite on the moneyline. When Bradley starts, the Twins have gone 18-9-0 against the spread. The Twins have been the moneyline underdog in 16 of Bradley's starts this season, and they went 10-6 in those matchups.

Guardians vs Twins Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Twins win (52.1%)

Guardians vs Twins Moneyline

• Minnesota is the underdog, +102 on the moneyline, while Cleveland is a -120 favorite despite being on the road.

Guardians vs Twins Spread

• The Guardians are at the Twins and are favored by 1.5 runs on the spread. The Guardians are +138 to cover the runline, with the Twins being -166.

Guardians vs Twins Over/Under

• A combined run total of 7.5 has been set for Guardians-Twins on Sept. 11, with the over at -110 and the under at -110.

Bet on Cleveland Guardians vs. Minnesota Twins on FanDuel today!

Guardians vs Twins Betting Trends

• The Guardians have won in 42, or 50.6%, of the 83 contests they have been named as odds-on favorites in this year.
• This year Cleveland has won 35 of 66 games when listed as at least -120 on the moneyline.
• The Guardians and their opponents have hit the over in 68 of their 139 games with a total set by oddsmakers this season.
• The Guardians are 65-74-0 against the spread in their 139 games with a line set by sportsbooks this season.
• The Twins have won 38 of the 86 games they were the moneyline underdog this season (44.2%).
• In games it has played as a moneyline underdog with odds of +102 or longer, Minnesota has a record of 33-41 (44.6%).
• The Twins have had an over/under set by oddsmakers 142 times, and have combined with opponents to go over the total in 80 of those games (80-59-3).
• The Twins have a 77-65-0 record ATS this season (covering 54.2% of the time).

Guardians Player Leaders

• Chase DeLauter leads Cleveland with 133 hits, batting .296 this season with 45 extra-base hits. He has an on-base percentage of .365 and a slugging percentage of .464.
• Among qualified hitters, he is ninth in batting average, his on-base percentage ranks 23rd, and he is 37th in slugging.
• Jose Ramirez is batting .234 with 24 doubles, 11 home runs and 57 walks. He's slugging .371 with an on-base percentage of .326.
• He is 108th in batting average, 71st in on-base percentage and 116th in slugging in MLB.
• Steven Kwan is slashing .275/.371/.336 this season and leads the Guardians with an OPS of .708.
• Kwan heads into this game with four games in a row with at least one hit. In his last five games he is hitting .318 with three doubles.
• Brayan Rocchio is batting .247 with a .305 OBP and 62 RBI for Cleveland this season.

Twins Player Leaders

• Brooks Lee is hitting .248 with 23 doubles, three triples, 23 home runs and 34 walks. He's slugging .435 with an on-base percentage of .297.
• He ranks 81st in batting average, 121st in on-base percentage and 56th in slugging percentage among all qualifying hitters in the majors.
• Josh Bell leads his team with a .425 slugging percentage. He has a batting average of .256 with an on-base percentage of .319.
• He ranks 67th in batting average, 86th in on-base percentage and 67th in slugging percentage in the big leagues.
• Kody Clemens has racked up 113 hits, a team-high for the Twins.
• Luke Keaschall leads his team with a .368 on-base percentage.

Guardians vs Twins Head to Head

• 7/23/2026: 3-1 MIN (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 7/22/2026: 10-6 MIN (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 7/21/2026: 5-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 7/20/2026: 13-4 CLE (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 7/9/2026: 5-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 7/8/2026: 6-5 MIN (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 7/7/2026: 3-1 MIN (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 5/10/2026: 5-4 MIN (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 5/8/2026: 6-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 9/21/2025: 6-2 MIN (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -144, Underdog Moneyline: +122)

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