Guardians vs Twins Prediction, Odds, Moneyline, Spread & Over/Under for May 10

Odds updated as of 4:12 a.m.

In MLB action on Sunday, the Cleveland Guardians play the Minnesota Twins.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information regarding this game.

Guardians vs Twins Game Info

• Cleveland Guardians (21-20) vs. Minnesota Twins (17-23)
• Date: Sunday, May 10, 2026
• Time: 1:40 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CleGuardians.TV and Twins.TV

Guardians vs Twins Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-146) | MIN: (+124)
• Spread: CLE: -1.5 (+146) | MIN: +1.5 (-178)
• Total: 7.5 -- Over: (-115) | Under: (-105)

Guardians vs Twins Probable Starting Pitchers

Probable Pitchers: Gavin Williams (Guardians) - 5-2, 3.28 ERA vs Andrew Morris (Twins) - 1-1, 4.96 ERA

The Guardians will give the ball to Gavin Williams (5-2, 3.28 ERA), who is eyeing win No. 6 on the season, and the Twins will turn to Andrew Morris (1-1, 4.96 ERA). Williams and his team are 5-2-0 ATS this season when he starts. Williams' team has a record of 4-1 this season when he starts and they are the favorite on the moneyline. Morris did not pitch as a moneyline underdog a season ago.

Guardians vs Twins Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Twins win (50.6%)

Guardians vs Twins Moneyline

• Cleveland is a -146 favorite on the moneyline, while Minnesota is a +124 underdog on the road.

Guardians vs Twins Spread

• The Guardians are favored by 1.5 runs at home against the Twins. The Guardians are +146 to cover the spread, while the Twins are -178.

Guardians vs Twins Over/Under

• An over/under of 7.5 has been set for Guardians-Twins on May 10, with the over being -115 and the under -105.

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Guardians vs Twins Betting Trends

• The Guardians have been favorites in 18 games this season and have come away with the win nine times (50%) in those contests.
• This season Cleveland has come away with a win two times in three chances when named as a favorite of at least -146 on the moneyline.
• The Guardians' games have gone over the total in 20 of their 39 opportunities.
• In 39 games with a line this season, the Guardians have a mark of 21-18-0 against the spread.
• The Twins have been the underdog on the moneyline 28 total times this season. They've gone 12-16 in those games.
• When it has played as a moneyline underdog with odds of +124 or longer, Minnesota has gone 6-5 (54.5%).
• The Twins have played in 39 games with a set over/under, and have combined with opponents to go over the total 25 times (25-13-1).
• The Twins have gone 18-21-0 against the spread this season.

Guardians Player Leaders

• Jose Ramirez is batting .221 with eight doubles, six home runs and 30 walks. He has an on-base percentage of .352 while slugging .396.
• Among qualifying batters in baseball, his batting average ranks 135th, his on-base percentage ranks 58th, and he is 92nd in slugging.
• Ramirez will look for his fourth straight game with a hit in this matchup. In his last five games he is hitting .250 with six walks and an RBI.
• Chase DeLauter leads Cleveland with 38 hits and an OBP of .378, plus a team-best slugging percentage of .527. He's batting .295.
• Among all qualified, he ranks 27th in batting average, 30th in on-base percentage and 21st in slugging percentage.
• Brayan Rocchio is batting .256 with a .357 slugging percentage and 19 RBI this year.
• Steven Kwan has one home run, nine RBI and a batting average of .214 this season.

Twins Player Leaders

• Byron Buxton has racked up a team-best slugging percentage (.563) while pacing the Twins in hits (41). He's batting .259 and with an on-base percentage of .310.
• Including all qualified hitters in MLB, his batting average places him 69th, his on-base percentage is 121st, and he is 12th in slugging.
• Buxton hopes to build on a three-game hitting streak in this matchup. During his last five outings he is hitting .292 with two doubles, three home runs and seven RBIs.
• Ryan Jeffers has five doubles, a triple, five home runs and 18 walks while hitting .300. He's slugging .520 with an on-base percentage of .408.
• Brooks Lee has an on-base percentage of .319, a team-best for the Twins.
• Luke Keaschall's .319 OBP paces his team.

Guardians vs Twins Head to Head

• 5/8/2026: 6-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 9/21/2025: 6-2 MIN (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 9/20/2025: 8-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/20/2025: 6-0 CLE (Favorite: Twins, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 9/19/2025: 6-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/3/2025: 5-4 MIN (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 8/2/2025: 5-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 7, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 8/1/2025: 3-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 5/21/2025: 5-1 CLE (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/1/2025: 4-3 CLE (Favorite: Twins, Spread: -1.5, Total: 9, Favorite Moneyline: -124, Underdog Moneyline: +106)

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