Guardians vs Tigers Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 6

Odds updated as of 1:12 p.m.

The Cleveland Guardians versus the Detroit Tigers is on the MLB schedule for Sunday.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital info regarding this matchup.

Guardians vs Tigers Game Info

• Cleveland Guardians (72-71) vs. Detroit Tigers (65-77)
• Date: Sunday, September 6, 2026
• Time: 1:40 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CleGuardians.TV and DSN

Guardians vs Tigers Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-166) | DET: (+140)
• Spread: CLE: -1.5 (+132) | DET: +1.5 (-160)
• Total: 7 -- Over: (-102) | Under: (-120)

Guardians vs Tigers Probable Starting Pitchers

Probable Pitchers: Gavin Williams (Guardians) - 13-7, 3.81 ERA vs Jackson Jobe (Tigers) - 1-2, 4.63 ERA

This contest's pitching matchup is set, as the Guardians will send Gavin Williams (13-7) to the mound, while Jackson Jobe (1-2) will get the nod for the Tigers. Williams' team is 14-13-0 against the spread this season in his starts. When Williams starts a game and his team is the favorite on the moneyline, they have a record of 13-9. When Jobe starts, the Tigers are 3-2-0 against the spread. The Tigers have been the underdog on the moneyline in three of Jobe's starts this season, and they went 1-2 in those matchups.

Guardians vs Tigers Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (53.3%)

Guardians vs Tigers Moneyline

• Looking at the moneyline for Tigers-Guardians, Detroit is the underdog at +140, and Cleveland is -166 playing at home.

Guardians vs Tigers Spread

• The Guardians are favored by 1.5 runs at home versus the Tigers. The Guardians are +132 to cover the spread, while the Tigers are -160.

Guardians vs Tigers Over/Under

• An over/under of 7 has been set for Guardians-Tigers on Sept. 6, with the over being -102 and the under -120.

Bet on Cleveland Guardians vs. Detroit Tigers on FanDuel today!

Guardians vs Tigers Betting Trends

• The Guardians have been victorious in 41, or 50.6%, of the 81 contests they have been chosen as favorites in this season.
• This year Cleveland has won six of nine games when listed as at least -166 on the moneyline.
• The Guardians and their opponents have gone over the total this season in 65 of their 135 opportunities.
• The Guardians are 64-71-0 against the spread in their 135 games with a line set by sportsbooks this season.
• The Tigers have compiled a 26-33 record in games they were the underdog on the moneyline (winning 44.1% of those games).
• When it has played as a moneyline underdog with odds of +140 or longer, Detroit has a 1-3 record (winning just 25% of its games).
• The Tigers have had an over/under set by oddsmakers 137 times, and have combined with opponents to go over the total in 59 of those games (59-75-3).
• The Tigers have put together a 70-67-0 record against the spread this season (covering 51.1% of the time).

Guardians Player Leaders

• Chase DeLauter leads Cleveland with 131 hits and a team-best slugging percentage of .458. He's batting .294 with an on-base percentage of .365.
• Among qualifying hitters in baseball, he is 10th in batting average, 21st in on-base percentage, and 42nd in slugging.
• Jose Ramirez is batting .237 with 24 doubles, 11 home runs and 56 walks. He's slugging .378 with an on-base percentage of .330.
• He ranks 107th in batting average, 73rd in on-base percentage and 111th in slugging among qualified hitters.
• Steven Kwan leads Cleveland with an OBP of .371 this season while batting .270 with 73 walks and 69 runs scored.
• Brayan Rocchio has 12 home runs, 59 RBI and a batting average of .246 this season.

Tigers Player Leaders

• Kevin McGonigle has a team-best OBP (.372) and slugging percentage (.410). He's batting .272.
• Including all the qualifying players in the majors, his batting average is 38th, his on-base percentage is 13th, and he is 83rd in slugging.
• Dillon Dingler paces his team with 123 hits. He has a batting average of .247 while slugging .462 with an on-base percentage of .310.
• Including all qualified players, his batting average places him 86th, his on-base percentage ranks 102nd, and he is 38th in slugging.
• Riley Greene is batting .273 with 27 doubles, a triple, 18 home runs and 62 walks.
• Spencer Torkelson is hitting .222 with 24 doubles, 22 home runs and 58 walks.

Guardians vs Tigers Head to Head

• 9/5/2026: 6-0 DET (Favorite: Guardians, Spread: -1.5, Total: 7, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 8/13/2026: 3-0 DET (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -108, Underdog Moneyline: +100)
• 8/12/2026: 6-4 CLE (Favorite: Tigers, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +114)
• 8/11/2026: 6-4 DET (Favorite: Tigers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +124)
• 6/13/2026: 3-1 CLE (Favorite: Tigers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 6/12/2026: 3-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 5/21/2026: 3-1 CLE (Favorite: Tigers, Spread: -1.5, Total: 7, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 5/20/2026: 3-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 5/19/2026: 4-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 10/2/2025: 6-3 DET (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!