Guardians vs Tigers Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 4

Odds updated as of 4:12 p.m.

Friday's slate in the MLB includes a matchup between the Cleveland Guardians and the Detroit Tigers.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Guardians vs Tigers Game Info

• Cleveland Guardians (70-70) vs. Detroit Tigers (64-75)
• Date: Friday, September 4, 2026
• Time: 7:15 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: Apple TV+

Guardians vs Tigers Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-126) | DET: (+108)
• Spread: CLE: -1.5 (+164) | DET: +1.5 (-200)
• Total: 8.5 -- Over: (-102) | Under: (-120)

Guardians vs Tigers Probable Starting Pitchers

Probable Pitchers: Foster Griffin (Guardians) - 15-4, 3.21 ERA vs Andrew Sears (Tigers) - 0-1, 6.75 ERA

This contest's pitching matchup is set, as the Guardians will send Foster Griffin (15-4) to the mound, while Andrew Sears (0-1) will take the ball for the Tigers. When Griffin starts, his team is 17-9-0 against the spread this season. Griffin's team has been victorious in 77.8% of the games he's started as the moneyline favorite with a record of 7-2. Sears and his team were underdogs on the moneyline in every game he pitched a season ago.

Guardians vs Tigers Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Tigers win (53.4%)

Guardians vs Tigers Moneyline

• Looking at the moneyline for Guardians-Tigers, Cleveland is the favorite at -126, and Detroit is +108 playing on the road.

Guardians vs Tigers Spread

• The Tigers are +1.5 on the spread (-200 to cover), and Cleveland is +164 to cover the runline.

Guardians vs Tigers Over/Under

• The Guardians-Tigers game on Sept. 4 has been given an over/under of 8.5 runs. The over is set at -102 and the under at -120.

Bet on Cleveland Guardians vs. Detroit Tigers on FanDuel today!

Guardians vs Tigers Betting Trends

• The Guardians have been chosen as favorites in 80 games this year and have walked away with the win 41 times (51.2%) in those games.
• This year Cleveland has won 26 of 53 games when listed as at least -126 on the moneyline.
• Contests with the Guardians have gone over the total set by oddsmakers in 65 of 134 chances this season.
• The Guardians have an against the spread mark of 64-70-0 in 134 games with a line this season.
• The Tigers have won 25 of the 58 games they were listed as the moneyline underdog this season (43.1%).
• In games it has played as a moneyline underdog with odds of +108 or longer, Detroit has gone 11-17 (39.3%).
• The Tigers have combined with opponents to go over the total 59 times this season for a 59-74-3 record against the over/under.
• The Tigers have gone 69-67-0 ATS this season.

Guardians Player Leaders

• Chase DeLauter leads Cleveland in slugging percentage (.455) and total hits (129) this season. He's batting .293 with an on-base percentage of .363.
• Among the qualifying batters in the majors, his batting average ranks 10th, his on-base percentage ranks 23rd, and he is 42nd in slugging.
• DeLauter has recorded at least one hit in two straight games. In his last five games he is batting .381 with four doubles and an RBI.
• Jose Ramirez is batting .241 with 24 doubles, 11 home runs and 56 walks, while slugging .386 with an on-base percentage of .334.
• Among qualifying hitters, his batting average ranks him 97th, his on-base percentage 65th, and his slugging percentage 101st.
• Steven Kwan leads Cleveland in OBP (.374) this season, fueled by 126 hits.
• Jo Adell has 20 home runs, 83 RBI and a batting average of .241 this season.

Tigers Player Leaders

• Kevin McGonigle has put up an on-base percentage of .372 and a slugging percentage of .410. Both lead the Tigers. He's batting .271.
• Including all qualifying players in MLB, he is 43rd in batting average, 13th in on-base percentage and 83rd in slugging percentage.
• Dillon Dingler has 121 hits to lead his team. He has a batting average of .248 while slugging .466 with an on-base percentage of .313.
• Including all qualifying hitters, he is 84th in batting average, 101st in on-base percentage and 37th in slugging percentage.
• Riley Greene has 26 doubles, a triple, 16 home runs and 61 walks while batting .269.
• Spencer Torkelson is hitting .221 with 24 doubles, 21 home runs and 58 walks.

Guardians vs Tigers Head to Head

• 8/13/2026: 3-0 DET (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -108, Underdog Moneyline: +100)
• 8/12/2026: 6-4 CLE (Favorite: Tigers, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +114)
• 8/11/2026: 6-4 DET (Favorite: Tigers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +124)
• 6/13/2026: 3-1 CLE (Favorite: Tigers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 6/12/2026: 3-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 5/21/2026: 3-1 CLE (Favorite: Tigers, Spread: -1.5, Total: 7, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 5/20/2026: 3-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 5/19/2026: 4-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 10/2/2025: 6-3 DET (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 10/1/2025: 6-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 7, Favorite Moneyline: -130, Underdog Moneyline: +110)

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