Guardians vs Tigers Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 24

Odds updated as of 2:12 a.m.

The Cleveland Guardians versus the Detroit Tigers is on the MLB schedule for Wednesday.

We've got you covered, in terms of the vital information about this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Guardians vs Tigers Game Info

• Cleveland Guardians (85-72) vs. Detroit Tigers (85-72)
• Date: Wednesday, September 24, 2025
• Time: 6:40 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CLEG and FDSDET

Guardians vs Tigers Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-122) | DET: (+104)
• Spread: CLE: -1.5 (+168) | DET: +1.5 (-205)
• Total: 7.5 -- Over: (-108) | Under: (-112)

Guardians vs Tigers Probable Starting Pitchers

Probable Pitchers: Tanner Bibee (Guardians) - 11-11, 4.34 ERA vs Jack Flaherty (Tigers) - 8-14, 4.60 ERA

The Guardians will give the nod to Tanner Bibee (11-11, 4.34 ERA), who is eyeing win No. 12 on the season, and the Tigers will counter with Jack Flaherty (8-14, 4.60 ERA). Bibee and his team are 18-11-0 ATS this season when he starts. Bibee's team has a record of 10-5 this season when he starts and they are the favorite on the moneyline. When Flaherty starts, the Tigers are 10-19-0 against the spread. The Tigers are 2-6 in Flaherty's eight starts this season that they were the moneyline underdog.

Guardians vs Tigers Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Tigers win (54.5%)

Guardians vs Tigers Moneyline

• Cleveland is a -122 favorite on the moneyline, while Detroit is a +104 underdog on the road.

Guardians vs Tigers Spread

• The Guardians are hosting the Tigers and are favored by 1.5 runs (+168 to cover) on the runline. Detroit is -205 to cover.

Guardians vs Tigers Over/Under

• The over/under for the Guardians versus Tigers game on Sept. 24 has been set at 7.5, with -108 odds on the over and -112 odds on the under.

Bet on Cleveland Guardians vs. Detroit Tigers on FanDuel today!

Guardians vs Tigers Betting Trends

• The Guardians have come away with 42 wins in the 65 contests they have been listed as the favorites in this season.
• This year Cleveland has won 29 of 42 games when listed as at least -122 on the moneyline.
• Contests with the Guardians have gone over the total set by bookmakers in 66 of 154 chances this season.
• The Guardians are 85-69-0 against the spread in their 154 games with a line set by sportsbooks this season.
• The Tigers have been the underdog on the moneyline 41 total times this season. They've gone 20-21 in those games.
• In games it has played as a moneyline underdog with odds of +104 or longer, Detroit has a 9-15 record (winning only 37.5% of its games).
• In the 151 games oddsmakers have set an over/under for the Tigers, they have combined with opponents to go over the total 78 times (78-67-6).
• The Tigers have collected a 70-81-0 record against the spread this season (covering 46.4% of the time).

Guardians Player Leaders

• Jose Ramirez leads Cleveland in OBP (.359) and total hits (162) this season. He's batting .282 batting average while slugging .503.
• Among qualified hitters in MLB, his batting average ranks 20th, his on-base percentage ranks 21st, and he is 15th in slugging.
• Ramirez has hit safely in six straight games. During his last 10 outings he is batting .278 with two doubles, two home runs, seven walks and five RBIs.
• Steven Kwan has hit 11 homers this season while driving in 55 runs. He's batting .277 this season and slugging .383 with an on-base percentage of .336.
• Among qualifying batters, he ranks 28th in batting average, 58th in on-base percentage and 121st in slugging percentage.
• Kwan brings a five-game streak with at least one hit into this contest. During his last five outings he is hitting .409 with two doubles, a home run, a walk and six RBIs.
• Kyle Manzardo is batting .236 with a .457 slugging percentage and 68 RBI this year.
• Manzardo brings a three-game hitting streak into this game. During his last five outings he is batting .158 with a double, a walk and an RBI.
• Angel Martinez has 11 home runs, 45 RBI and a batting average of .228 this season.

Tigers Player Leaders

• Gleyber Torres a has .364 on-base percentage to lead the Tigers. He's batting .259 while slugging .395.
• Including all the qualified hitters in MLB, his batting average ranks 65th, his on-base percentage ranks 15th, and he is 109th in slugging.
• Riley Greene's 153 hits and .497 slugging percentage both pace his team. He has a batting average of .261 with an on-base percentage of .315.
• Including all qualifying players, he is 59th in batting average, 100th in on-base percentage and 17th in slugging percentage.
• Spencer Torkelson is hitting .241 with 27 doubles, a triple, 31 home runs and 70 walks.
• Zach McKinstry is hitting .260 with 23 doubles, 11 triples, 12 home runs and 46 walks.

Guardians vs Tigers Head to Head

• 9/23/2025: 5-2 CLE (Favorite: Tigers, Spread: -1.5, Total: 6.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 9/18/2025: 3-1 CLE (Favorite: Tigers, Spread: -1.5, Total: 7, Favorite Moneyline: -235, Underdog Moneyline: +194)
• 9/17/2025: 4-0 CLE (Favorite: Tigers, Spread: -1.5, Total: 8, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 9/16/2025: 7-5 CLE (Favorite: Tigers, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/6/2025: 7-2 DET (Favorite: Tigers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 7/5/2025: 1-0 DET (Favorite: Tigers, Spread: -1.5, Total: 9, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 7/4/2025: 2-1 DET (Favorite: Tigers, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/25/2025: 5-0 DET (Favorite: Tigers, Spread: -1.5, Total: 7, Favorite Moneyline: -290, Underdog Moneyline: +235)
• 5/24/2025: 7-5 CLE (Favorite: Tigers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/23/2025: 3-1 CLE (Favorite: Tigers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)

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