Guardians vs Reds Prediction, Odds, Moneyline, Spread & Over/Under for May 16

Odds updated as of 5:13 a.m.

In MLB action on Friday, the Cleveland Guardians face the Cincinnati Reds.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Guardians vs Reds Game Info

• Cleveland Guardians (25-18) vs. Cincinnati Reds (21-24)
• Date: Friday, May 16, 2025
• Time: 6:40 p.m. ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: FDSOH and CLEG

Guardians vs Reds Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-124) | CIN: (+106)
• Spread: CLE: -1.5 (+122) | CIN: +1.5 (-146)
• Total: 9 -- Over: (-106) | Under: (-114)

Guardians vs Reds Probable Starting Pitchers

Probable Pitchers: Tanner Bibee (Guardians) - 3-3, 3.80 ERA vs Brady Singer (Reds) - 4-2, 4.97 ERA

This contest's pitching matchup is set, as the Guardians will send Tanner Bibee (3-3) to the mound, while Brady Singer (4-2) will get the nod for the Reds. When Bibee starts, his team is 3-4-0 against the spread this season. Bibee's team has a record of 3-1 this season when he starts and they are the favorite on the moneyline. The Reds are 5-3-0 against the spread when Singer starts. The Reds are 3-1 in Singer's four starts this season that they were the moneyline underdog.

Guardians vs Reds Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Reds win (55.8%)

Guardians vs Reds Moneyline

• Cleveland is a -124 favorite on the moneyline, while Cincinnati is a +106 underdog at home.

Guardians vs Reds Spread

• The Reds are at +1.5 on the runline against the Guardians. The Reds are -146 to cover the spread, and the Guardians are +122.

Guardians vs Reds Over/Under

• Guardians versus Reds on May 16 has an over/under of 9 runs, with the odds on the over -106 and the under set at -114.

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Guardians vs Reds Betting Trends

• The Guardians have been victorious in 11, or 68.8%, of the 16 contests they have been chosen as favorites in this season.
• This season Cleveland has come away with a win seven times in nine chances when named as a favorite of at least -124 on the moneyline.
• The Guardians' games have gone over the total in 22 of their 42 opportunities.
• The Guardians are 20-22-0 against the spread in their 42 games with a line set by sportsbooks this season.
• The Reds have a 10-14 record in games they were the underdog on the moneyline (winning 41.7% of those games).
• Cincinnati is 6-9 (winning 40% of its games) when it has played as a moneyline underdog of +106 or longer.
• In the 43 games oddsmakers have set an over/under for the Reds, they have combined with opponents to go over the total 18 times (18-24-1).
• The Reds have a 22-21-0 record ATS this season (covering 51.2% of the time).

Guardians Player Leaders

• Jose Ramirez leads Cleveland in total hits (44) this season while batting .295 with 16 extra-base hits. He has an on-base percentage of .363 and a slugging percentage of .510.
• Among qualified hitters in MLB, his batting average ranks 23rd, his on-base percentage ranks 43rd, and he is 23rd in slugging.
• Ramirez will look for his 10th straight game with a hit in this contest. During his last 10 outings he is batting .361 with three doubles, three home runs, seven walks and seven RBIs.
• Steven Kwan leads the Guardians with an OPS of .833. He has a slash line of .325/.384/.450 this season.
• Among qualifying hitters, his batting average ranks him sixth, his on-base percentage 20th, and his slugging percentage 61st.
• Kyle Manzardo is batting .221 with a .504 slugging percentage and 25 RBI this year.
• Manzardo has picked up a hit in three straight games. During his last five outings he is hitting .222 with a triple, a home run and three RBIs.
• Carlos Santana has been key for Cleveland with 31 hits, an OBP of .331 plus a slugging percentage of .326.

Reds Player Leaders

• Elly De La Cruz has a slugging percentage of .426 and has 45 hits, both team-high numbers for the Reds. He's batting .256 and with an on-base percentage of .327.
• Including all the qualified hitters in the big leagues, he ranks 78th in batting average, 87th in on-base percentage and 74th in slugging percentage.
• De La Cruz hopes to build on a three-game hitting streak in this matchup. In his last five games he is hitting .286 with a double, three home runs and six RBIs.
• TJ Friedl is batting .274 with six doubles, a triple, three home runs and 20 walks. He's slugging .382 with an on-base percentage of .359.
• Including all qualified hitters, he ranks 52nd in batting average, 47th in on-base percentage and 108th in slugging percentage.
• Gavin Lux a has .383 on-base percentage to lead the Reds.
• Matt McLain is batting .182 with three doubles, six home runs and 21 walks.

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