Guardians vs Nationals Prediction, Odds, Moneyline, Spread & Over/Under for May 6

Odds updated as of 1:11 a.m.

Tuesday's slate in the MLB includes a matchup between the Cleveland Guardians and the Washington Nationals.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Guardians vs Nationals Game Info

• Cleveland Guardians (20-14) vs. Washington Nationals (16-19)
• Date: Tuesday, May 6, 2025
• Time: 3:35 p.m. ET
• Venue: Nationals Park -- Washington, District of Columbia
• Coverage: MASN2 and CLEG

Guardians vs Nationals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-118) | WSH: (-100)
• Spread: CLE: -1.5 (+146) | WSH: +1.5 (-176)
• Total: 9 -- Over: (-122) | Under: (-100)

Guardians vs Nationals Probable Starting Pitchers

Probable Pitchers: Luis Ortiz (Guardians) - 2-3, 4.78 ERA vs Jake Irvin (Nationals) - 2-1, 4.01 ERA

The Guardians will call on Luis Ortiz (2-3) against the Nationals and Jake Irvin (2-1). Ortiz and his team are 3-3-0 ATS this season when he starts. Ortiz's team has a record of 2-1 this season when he starts and they are the favorite on the moneyline. The Nationals have a 3-4-0 record against the spread in Irvin's starts. The Nationals are 3-4 in Irvin's seven starts this season that they were the underdog on the moneyline.

Guardians vs Nationals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (53.6%)

Guardians vs Nationals Moneyline

• Washington is the underdog, -100 on the moneyline, while Cleveland is a -118 favorite despite being on the road.

Guardians vs Nationals Spread

• The Guardians are favored by 1.5 runs on the road against the Nationals. The Guardians are +146 to cover the spread, while the Nationals are -176.

Guardians vs Nationals Over/Under

• The over/under for the Guardians versus Nationals contest on May 6 has been set at 9, with -122 odds on the over and -100 odds on the under.

Bet on Cleveland Guardians vs. Washington Nationals on FanDuel today!

Guardians vs Nationals Betting Trends

• The Guardians have come away with nine wins in the 12 contests they have been listed as the favorites in this season.
• This season Cleveland has come away with a win six times in eight chances when named as a favorite of at least -118 on the moneyline.
• The Guardians and their opponents have hit the over in 18 of their 33 games with a total set by oddsmakers this season.
• The Guardians are 15-18-0 against the spread in their 33 games that had a posted line this season.
• The Nationals have won 50% of the games this season they were the moneyline underdog (13-13).
• In games it has played as a moneyline underdog with odds of -100 or longer, Washington has a 12-12 record (winning 50% of its games).
• The Nationals have played in 33 games with a set over/under, and have combined with their opponents to go over the total 17 times (17-16-0).
• The Nationals are 19-14-0 ATS this season.

Guardians Player Leaders

• Steven Kwan leads Cleveland OPS (.850) this season. He has a .333 batting average, an on-base percentage of .384, and a slugging percentage of .467.
• Among qualifying hitters in baseball, he is fifth in batting average, 24th in on-base percentage, and 45th in slugging.
• Kwan will look for his fourth straight game with a hit in this contest. In his last five games he is batting .333 with a double, two walks and an RBI.
• Jose Ramirez has five doubles, five home runs and 10 walks. He's batting .265 and slugging .436 with an on-base percentage of .318.
• His batting average is 58th among qualified players, his on-base percentage 87th, and his slugging percentage 59th.
• Kyle Manzardo leads Cleveland with 23 hits. He is batting .219 this season and 12 of his hits have gone for extra bases.
• Carlos Santana has three home runs, 10 RBI and a batting average of .219 this season.

Nationals Player Leaders

• James Wood has an on-base percentage of .381, a slugging percentage of .545, and has 36 hits, all club-highs for the Nationals (while batting .273).
• Including all qualifying hitters, he is 50th in batting average, while his on-base percentage is 26th and he is 17th in slugging.
• Wood hopes to build on a four-game hitting streak in this matchup. In his last five games he is batting .368 with two doubles and four walks.
• Nathaniel Lowe is hitting .254 with seven doubles, six home runs and 14 walks. He's slugging .446 with an on-base percentage of .331.
• Including all qualified players, he is 75th in batting average, 71st in on-base percentage and 54th in slugging percentage.
• Luis Garcia has five doubles, three home runs and eight walks while batting .234.
• C.J. Abrams has five doubles, two triples, four home runs and four walks while hitting .284.

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