Guardians vs Athletics Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 20

Odds updated as of 8:11 p.m.

MLB action on Sunday includes the Cleveland Guardians taking on the Athletics.

All the information you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Guardians vs Athletics Game Info

• Cleveland Guardians (79-75) vs. Athletics (61-93)
• Date: Sunday, September 20, 2026
• Time: 1:40 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CleGuardians.TV and NBCS-CA

Guardians vs Athletics Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-230) | OAK: (+190)
• Spread: CLE: -1.5 (+105) | OAK: +1.5 (-126)
• Total: 6.5 -- Over: (-140) | Under: (+114)

Guardians vs Athletics Probable Starting Pitchers

Probable Pitchers: Gavin Williams (Guardians) - 13-8, 3.78 ERA vs Jack Perkins (Athletics) - 3-11, 6.14 ERA

The Guardians will look to Gavin Williams (13-8) versus the Athletics and Jack Perkins (3-11). Williams' team is 14-15-0 against the spread in his starts this season. Williams' team has been victorious in 58.3% of the games he's started as the moneyline favorite with a record of 14-10. The Athletics have a 4-11-0 ATS record in Perkins' 15 starts with a set spread. The Athletics have a 1-9 record in Perkins' 10 starts this season when they were the moneyline underdog.

Guardians vs Athletics Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (56.5%)

Guardians vs Athletics Moneyline

• The Guardians vs Athletics moneyline has the Guardians as a -230 favorite, while the Athletics are a +190 underdog on the road.

Guardians vs Athletics Spread

• The Guardians are 1.5-run favorites on the runline against the Athletics. The Guardians are +105 to cover, while the Athletics are -126 to cover.

Guardians vs Athletics Over/Under

• A total of 6.5 runs has been set for the Guardians-Athletics contest on Sept. 20, with the over available at -140 and the under at +114.

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Guardians vs Athletics Betting Trends

• The Guardians have been victorious in 46, or 52.3%, of the 88 contests they have been chosen as favorites in this season.
• The Guardians have been named as a favorite of -230 or more just one time this season and came away with a victory in that game.
• The Guardians and their opponents have hit the over in 72 of their 146 games with a total this season.
• The Guardians have an against the spread mark of 69-77-0 in 146 games with a line this season.
• The Athletics have been the moneyline underdog 117 total times this season. They've finished 45-72 in those games.
• When they have played as a moneyline underdog with odds of +190 or longer, the Athletics have gone 5-6 (45.5%).
• The Athletics have played in 154 games with a set over/under, and have combined with their opponents to go over the total 79 times (79-73-2).
• The Athletics have put together a 73-81-0 record against the spread this season.

Guardians Player Leaders

• Chase DeLauter leads Cleveland in total hits (135) this season while batting .289 with 45 extra-base hits. He has an on-base percentage of .363 and a slugging percentage of .452.
• Among the qualified hitters in MLB, his batting average ranks 12th, his on-base percentage ranks 24th, and he is 43rd in slugging.
• Steven Kwan is slashing .275/.376/.342 this season and leads the Guardians with an OPS of .717.
• Among qualifying batters, he is 34th in batting average, 12th in on-base percentage and 130th in slugging percentage.
• Jose Ramirez has 103 hits this season and has a slash line of .232/.320/.372.
• Ramirez enters this game with two games in a row with at least one hit. During his last five outings he is batting .238 with two doubles, a home run and three RBIs.
• Brayan Rocchio has been key for Cleveland with 128 hits, an OBP of .312 plus a slugging percentage of .379.

Athletics Player Leaders

• Jeff McNeil has accumulated a team-best .369 slugging percentage. He's batting .268 with an on-base percentage of .315.
• Including all the qualified hitters in the big leagues, he ranks 44th in batting average, 94th in on-base percentage and 116th in slugging percentage.
• Shea Langeliers has 19 doubles, 23 home runs and 34 walks while batting .263. He's slugging .487 with an on-base percentage of .329.
• Zack Gelof has 15 doubles, two triples, 19 home runs and 29 walks while batting .247.
• Lawrence Butler's 101 hits and .321 OBP both pace his team.

Guardians vs Athletics Head to Head

• 9/18/2026: 5-3 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -240, Underdog Moneyline: +198)
• 5/3/2026: 7-1 OAK (Favorite: Guardians, Spread: -1.5, Total: 9.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/2/2026: 14-6 CLE (Favorite: Athletics, Spread: -1.5, Total: 10.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 5/1/2026: 8-5 CLE (Favorite: Guardians, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/20/2025: 8-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 7/19/2025: 8-2 OAK (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 7/18/2025: 8-6 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 6/22/2025: 3-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 6/21/2025: 4-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 9.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 6/20/2025: 5-1 OAK (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -124, Underdog Moneyline: +106)

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