Guardians vs Athletics Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 18

Odds updated as of 1:12 a.m.

On Friday in MLB, the Cleveland Guardians are playing the Athletics.

All the information you need to make smart bets on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Guardians vs Athletics Game Info

• Cleveland Guardians (78-75) vs. Athletics (61-92)
• Date: Friday, September 18, 2026
• Time: 7:10 p.m. ET
• Venue: Progressive Field -- Cleveland, Ohio
• Coverage: CleGuardians.TV and NBCS-CA

Guardians vs Athletics Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-198) | OAK: (+166)
• Spread: CLE: -1.5 (+114) | OAK: +1.5 (-137)
• Total: 8.5 -- Over: (-106) | Under: (-114)

Guardians vs Athletics Probable Starting Pitchers

Probable Pitchers: Daniel Espino (Guardians) - 0-0, 2.92 ERA vs Mason Barnett (Athletics) - 1-4, 7.08 ERA

The Guardians will give the ball to Daniel Espino and the Athletics will counter with Mason Barnett (1-4, 7.08 ERA). Espino and his team failed to cover the spread in his only opportunity this season as a starter. This will be Espino's first game as the moneyline favorite this season. The Athletics have a 2-2-0 record against the spread in Barnett's starts. The Athletics were the moneyline underdog for four Barnett starts this season -- they lost every game.

Guardians vs Athletics Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (59%)

Guardians vs Athletics Moneyline

• The Guardians vs Athletics moneyline has the Guardians as a -198 favorite, while the Athletics are a +166 underdog on the road.

Guardians vs Athletics Spread

• The Guardians are 1.5-run favorites on the runline against the Athletics. The Guardians are +114 to cover, while the Athletics are -137 to cover.

Guardians vs Athletics Over/Under

• The over/under for Guardians-Athletics on Sept. 18 is 8.5. The over is -106, and the under is -114.

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Guardians vs Athletics Betting Trends

• The Guardians have been favorites in 87 games this season and have come away with the win 45 times (51.7%) in those contests.
• The Guardians have been listed as a favorite of -198 or more on two occasions this season and split those games.
• The Guardians and their opponents have hit the over in 72 of their 145 games with a total this season.
• The Guardians are 68-77-0 against the spread in their 145 games with a line set by sportsbooks this season.
• The Athletics have won 38.8% of the games this season they were the underdog on the moneyline (45-71).
• The Athletics have a record of 7-11 when they have played as a moneyline underdog with odds of +166 or longer (38.9%).
• The Athletics have played in 153 games with a set over/under, and have combined with their opponents to go over the total 79 times (79-72-2).
• The Athletics have collected a 73-80-0 record against the spread this season (covering 47.7% of the time).

Guardians Player Leaders

• Chase DeLauter leads Cleveland with 134 hits, batting .289 this season with 45 extra-base hits. He has an on-base percentage of .362 and a slugging percentage of .453.
• Among qualifying hitters, he ranks 12th in batting average, his on-base percentage ranks 24th, and he is 43rd in slugging.
• Steven Kwan is slashing .277/.375/.344 this season and leads the Guardians with an OPS of .719.
• His batting average ranks 28th among qualified players, his on-base percentage 11th, and his slugging percentage 131st.
• Jose Ramirez has 101 hits this season and has a slash line of .230/.319/.364.
• Brayan Rocchio has 13 home runs, 67 RBI and a batting average of .248 this season.

Athletics Player Leaders

• Jeff McNeil has a .371 slugging percentage, which paces the Athletics. He's batting .268 with an on-base percentage of .315.
• Including all qualified hitters, he is 48th in batting average, while his on-base percentage ranks 98th and he is 117th in slugging.
• Shea Langeliers is batting .265 with 19 doubles, 23 home runs and 34 walks. He's slugging .492 with an on-base percentage of .332.
• Lawrence Butler has accumulated an on-base percentage of .319 and has 101 hits, both team-best numbers for the Athletics.
• Zack Gelof is hitting .247 with 15 doubles, two triples, 18 home runs and 29 walks.

Guardians vs Athletics Head to Head

• 5/3/2026: 7-1 OAK (Favorite: Guardians, Spread: -1.5, Total: 9.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/2/2026: 14-6 CLE (Favorite: Athletics, Spread: -1.5, Total: 10.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 5/1/2026: 8-5 CLE (Favorite: Guardians, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/20/2025: 8-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 7/19/2025: 8-2 OAK (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 7/18/2025: 8-6 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 6/22/2025: 3-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 6/21/2025: 4-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 9.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 6/20/2025: 5-1 OAK (Favorite: Guardians, Spread: -1.5, Total: 9, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 4/21/2024: 6-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -166, Underdog Moneyline: +140)

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