Guardians vs Angels Prediction, Odds, Moneyline, Spread & Over/Under for April 4

Odds updated as of 9:11 p.m.

The MLB's Friday slate includes the Cleveland Guardians facing the Los Angeles Angels.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Guardians vs Angels Game Info

• Cleveland Guardians (2-4) vs. Los Angeles Angels (4-2)
• Date: Friday, April 4, 2025
• Time: 9:38 p.m. ET
• Venue: Angel Stadium -- Anaheim, California
• Coverage: FDSW and CLEG

Guardians vs Angels Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CLE: (-116) | LAA: (-102)
• Spread: CLE: -1.5 (+146) | LAA: +1.5 (-178)
• Total: 8 -- Over: (-105) | Under: (-115)

Guardians vs Angels Probable Starting Pitchers

Probable Pitchers: Gavin Williams (Guardians) - 0-0, 3.60 ERA vs José Soriano (Angels) - 1-0, 0.00 ERA

The probable starters are Gavin Williams for the Guardians and Jose Soriano (1-0) for the Angels. Williams and his team failed to cover the spread in his only opportunity this season as a starter. Williams has yet to start a game this season when his team was the moneyline favorite. Soriano has started just one game with a set spread, which the Angels failed to cover. The Angels have yet to be named a moneyline underdog when Soriano starts this season.

Guardians vs Angels Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Guardians win (56.3%)

Guardians vs Angels Moneyline

• The moneyline numbers for Guardians vs. Angels reveal Cleveland as the favorite (-116) and Los Angeles as the underdog (-102) despite being the home team.

Guardians vs Angels Spread

• The Guardians are favored by 1.5 runs on the road versus the Angels. The Guardians are +146 to cover the spread, while the Angels are -178.

Guardians vs Angels Over/Under

• A total of 8 runs has been set for the Guardians-Angels game on April 4, with the over available at -105 and the under at -115.

Bet on Cleveland Guardians vs. Los Angeles Angels on FanDuel today!

Guardians vs Angels Betting Trends

• The Guardians have yet to play a game this season where they are listed as the favorite to win.
• These are the best odds of a victory sportsbooks have given Cleveland this season, with a -116 moneyline set for this game.
• The Guardians' games have gone over the total in three of their six opportunities.
• The Guardians have an against the spread mark of 2-4-0 in six games with a line this season.
• The Angels have won two of the three games they were the underdog on the moneyline this season (66.7%).
• Los Angeles has a 2-1 record (winning 66.7% of its games) when playing as a moneyline underdog of -102 or longer.
• The Angels have played in six games with an over/under set, and have combined with opponents to go over the total four times (4-2-0).
• The Angels have put together a 2-4-0 record ATS this season (covering just 33.3% of the time).

Guardians Player Leaders

• Kyle Manzardo has five hits, which is best among Cleveland hitters this season, while batting .250 with four extra-base hits. He has an on-base percentage of .333 and a slugging percentage of .700.
• Among all qualifying hitters in baseball, he ranks 87th in batting average, 77th in on-base percentage, and 19th in slugging.
• Steven Kwan has a slash line of .348/.400/.522 this season and a team-best OPS of .922.
• Among qualified hitters, he ranks 19th in batting average, 32nd in on-base percentage and 48th in slugging percentage.
• Kwan has picked up at least one hit in two games in a row. In his last five games he is batting .316 with a home run, two walks and two RBI.
• Carlos Santana has collected six base hits, an OBP of .308 and a slugging percentage of .348 this season.
• Jose Ramirez has been key for Cleveland with five hits, an OBP of .350 plus a slugging percentage of .588.

Angels Player Leaders

• Kyren Paris has a triple, a home run and two walks while hitting .444. He's slugging 1.000 with an on-base percentage of .545.
• Paris hopes to build on a four-game hitting streak in this matchup. During his last five outings he is hitting .444 with a triple, a home run, two walks and three RBI.
• Nolan Schanuel's seven hits and .417 slugging percentage both pace his team. He has a batting average of .292 with an on-base percentage of .320.
• Including all qualified hitters, he is 47th in batting average, 90th in on-base percentage and 84th in slugging percentage.
• Mike Trout is hitting .143 with a double, a home run and two walks.
• Logan O'Hoppe is batting .188 with two home runs.

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