East Carolina vs South Florida Prediction, Odds, Picks, Best Bets for Week 10 2026

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Friday's slate in college football includes a matchup between the East Carolina Pirates and the South Florida Bulls.

Get the latest NCAA football odds ahead of this matchup on FanDuel Sportsbook.

East Carolina vs South Florida Odds & Spread

All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
Moneyline: East Carolina: (-128) | South Florida: (+106)
Spread: East Carolina: -1.5 (-114) | South Florida: +1.5 (-106)
Total: 39.5 -- Over: (-108) | Under: (-112)

East Carolina has four wins in eight games against the spread this season.
As at least a 1.5-point favorite, East Carolina has two wins ATS (2-3).
Two of East Carolina's eight games have hit the over.
South Florida has beaten the spread four times in eight games.
South Florida has one win ATS (1-1) as a 1.5-point underdog or more this year.
South Florida has played eight games this season, and three of them have gone over the total.

All college football win probability predictions and picks are according to numberFire.
Prediction: Pirates win (53.7%)

South Florida is an underdog by 1.5 points against East Carolina. South Florida is -106 to cover the spread, and East Carolina is -114.

The over/under for the East Carolina versus South Florida game on Nov. 6 has been set at 39.5, with -108 odds on the over and -112 odds on the under.

The East Carolina vs South Florida moneyline has East Carolina as a -128 favorite, while South Florida is a +106 underdog.

	Point Scored (PG)	Points Scored CFB Rank	Points Allowed (PG)	Points Allowed CFB Rank	Average Total	Total Games
East Carolina	24.0	95	24.1	61	52.3	8
South Florida	27.0	78	14.5	10	49.9	8

Check out even more in-depth East Carolina vs. South Florida analysis on FanDuel Research.

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