Duke vs Louisville Basketball Prediction, Odds, Picks, Best Bets for ACC Tournament Championship

The ACC champion will be crowned Saturday as the No. 1 seed Duke Blue Devils (30-3, 19-1 ACC) play the No. 2 Louisville Cardinals (27-6, 18-2 ACC) at 8:30 p.m. ET.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Duke vs. Louisville Game Info and Odds

• Game day: Saturday, March 15, 2025
• Game time: 8:30 p.m. ET
• TV channel: ESPN
• Location: Charlotte, North Carolina
• Arena: Spectrum Center

Duke vs. Louisville Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Duke win (66%)

Before you decide to wager on Duke-Louisville outing (in which Duke is a 5.5-point favorite and the total has been set at 147.5 points), below are some betting insights and trends for Saturday's game.

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Duke vs. Louisville: ATS Betting Stats and Trends

• Duke has compiled a 21-12-0 ATS record so far this year.
• Louisville has covered 20 times in 33 chances against the spread this season.
• When the spread is set as 5.5 or more this season, Duke (19-11) covers a higher percentage of those games when it is the favorite (63.3%) than Louisville (1-1) does as the underdog (50%).
• The Blue Devils have covered the spread in a lower percentage of their home games than away games. They have covered 11 times in 17 games at home, and they've covered nine times in 11 games on the road.
• Against the spread, the Cardinals have had better results away (9-2-0) than at home (8-9-0).
• Duke has beaten the spread 14 times in 22 conference games.
• Louisville's ACC record against the spread is 15-7-0.

Duke vs. Louisville: Moneyline Betting Stats

• Duke has been chosen as the moneyline favorite in 31 games this year and has walked away with the win 28 times (90.3%) in those games.
• This season, the Blue Devils have been victorious 27 times in 29 chances when named as a favorite of at least -245 or better on the moneyline.
• Louisville has won four of the six games it was the moneyline underdog this season (66.7%).
• The Cardinals have played as a moneyline underdog of +198 or longer in just two games this season, which they lost both.
• Duke has an implied victory probability of 71% according to the moneyline set for this matchup.

Duke vs. Louisville Head-to-Head Comparison

• Duke is outscoring opponents by 21.1 points per game with a +696 scoring differential overall. It puts up 83.0 points per game (15th in college basketball) and allows 61.9 per contest (seventh in college basketball).
• Cooper Flagg is 47th in college basketball with a team-leading 18.9 points per game.
• Louisville outscores opponents by 10.3 points per game (posting 79.1 points per game, 55th in college basketball, and allowing 68.8 per outing, 80th in college basketball) and has a +340 scoring differential.
• Chucky Hepburn's team-leading 16.3 points per game rank him 162nd in the country.
• The 36.1 rebounds per game the Blue Devils average rank 17th in the country, and are 9.3 more than the 26.8 their opponents grab per outing.
• Flagg's 7.5 rebounds per game lead the Blue Devils and rank 108th in college basketball play.
• The Cardinals win the rebound battle by 4.8 boards on average. They collect 34.9 rebounds per game, 37th in college basketball, while their opponents grab 30.1.
• J'Vonne Hadley leads the team with 7.4 rebounds per game (121st in college basketball).
• Duke ranks first in college basketball with 110.4 points scored per 100 possessions, and fourth in college basketball defensively with 82.4 points conceded per 100 possessions.
• The Cardinals average 101.4 points per 100 possessions on offense (52nd in college basketball), and give up 88.2 points per 100 possessions (52nd in college basketball).

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