Duke vs Louisville Basketball Prediction, Odds, Picks, Best Bets for ACC Tournament Championship

The top-seeded Duke Blue Devils (29-3, 19-1 ACC) will meet the No. 2 seed Louisville Cardinals (26-6, 18-2 ACC) in the ACC championship game with an automatic berth in the NCAA Tournament up for grabs. The contest on Saturday at Spectrum Center tips off at 8:30 p.m. ET.

Before you place your bet on this matchup at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Duke vs. Louisville Game Info and Odds

• Game day: Saturday, March 15, 2025
• Game time: 8:30 p.m. ET
• TV channel: ESPN
• Location: Charlotte, North Carolina
• Arena: Spectrum Center

Duke vs. Louisville Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Duke win (66.1%)

Read these betting trends and insights before you bet on Saturday's Duke-Louisville spread (Duke -5.5) or total (144.5 points).

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Duke vs. Louisville: ATS Betting Stats and Trends

• Duke has won 21 games against the spread this season, while failing to cover 11 times.
• Louisville has compiled a 19-13-0 ATS record so far this season.
• When the spread is set as 5.5 or more this season, Duke (19-11) covers a higher percentage of those games when it is the favorite (63.3%) than Louisville (1-1) does as the underdog (50%).
• The Blue Devils sport a worse record against the spread when playing at home (11-6-0) than they do on the road (9-2-0).
• In 2024-25 against the spread, the Cardinals have a lower winning percentage at home (.471, 8-9-0 record) than away (.818, 9-2-0).
• Duke has beaten the spread 14 times in 21 conference games.
• Against the spread in ACC play, Louisville is 14-7-0 this year.

Duke vs. Louisville: Moneyline Betting Stats

• Duke has been the moneyline favorite in 30 games this season and has come away with the win 27 times (90%) in those contests.
• The Blue Devils have a win-loss record of 27-2 when favored by -240 or better by oddsmakers this year.
• Louisville has won 60% of the games this season it was the moneyline underdog (3-2).
• The Cardinals have played as a moneyline underdog of +195 or longer in only two games this season, which they lost both.
• The moneyline set for this matchup implies Duke has a 70.6% chance of walking away with the win.

Duke vs. Louisville Head-to-Head Comparison

• Duke's +693 scoring differential (outscoring opponents by 21.7 points per game) is a result of scoring 83.3 points per game (12th in college basketball) while giving up 61.6 per outing (sixth in college basketball).
• Duke's leading scorer, Cooper Flagg, ranks 47th in the country averaging 18.9 points per game.
• Louisville outscores opponents by 10.5 points per game (posting 79.2 points per game, 54th in college basketball, and allowing 68.7 per outing, 76th in college basketball) and has a +337 scoring differential.
• Louisville's leading scorer, Chucky Hepburn, ranks 159th in college basketball, scoring 16.4 points per game.
• The Blue Devils are 15th in college basketball at 36.3 rebounds per game. That's 9.5 more than the 26.8 their opponents average.
• Flagg tops the Blue Devils with 7.5 rebounds per game (107th in college basketball action).
• The Cardinals average 34.9 rebounds per game (38th in college basketball) while conceding 30.0 per contest to opponents. They outrebound opponents by 4.9 boards per game.
• J'Vonne Hadley tops the Cardinals with 7.3 rebounds per game (130th in college basketball).
• Duke averages 110.9 points per 100 possessions on offense (first in college basketball), and allows 82.0 points per 100 possessions (fourth in college basketball).
• The Cardinals score 101.6 points per 100 possessions (54th in college basketball), while allowing 88.1 points per 100 possessions (53rd in college basketball).

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