Duke vs Houston Basketball Prediction, Odds, Picks, Best Bets for NCAA Tournament Final Four

A Final Four matchup features the No. 1 seed Duke Blue Devils (35-3) and the No. 1 seed Houston Cougars (34-4) squaring off with a place in the national championship game up for grabs on Saturday at Alamodome. The NCAA Tournament matchup starts at 8:49 p.m. ET, on CBS.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Duke vs. Houston Game Info and Odds

• Game day: Saturday, April 5, 2025
• Game time: 8:49 p.m. ET
• TV channel: CBS
• Location: San Antonio, Texas
• Arena: Alamodome

Duke vs. Houston Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Duke win (59.7%)

Before you bet on Saturday's Duke-Houston spread (Duke -5.5) or total (136.5 points), take a look at the betting insights and trends below.

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Duke vs. Houston: ATS Betting Stats and Trends

• Duke has covered 25 times in 38 chances against the spread this season.
• Houston is 21-16-0 ATS this year.
• The Blue Devils have covered the spread in a lower percentage of their home games than road games. They have covered 11 times in 17 games at home, and they've covered nine times in 11 games on the road.
• The Cougars' winning percentage against the spread at home is .588 (10-7-0). On the road, it is .700 (7-3-0).

Duke vs. Houston: Moneyline Betting Stats

• Duke has been victorious in 33, or 91.7%, of the 36 contests it has been chosen as moneyline favorites in this season.
• The Blue Devils have a mark of 32-1 in contests where bookmakers favor them by -265 or better on the moneyline.
• Houston is playing as the moneyline underdog for the first time this season.
• The Cougars have not yet played a game with moneyline odds of +210 or longer.
• Duke has an implied victory probability of 72.6% according to the moneyline set for this matchup.

Duke vs. Houston Head-to-Head Comparison

• Duke outscores opponents by 21.1 points per game (scoring 83.7 per game to rank ninth in college basketball while giving up 62.6 per outing to rank seventh in college basketball) and has a +801 scoring differential overall.
• Cooper Flagg's team-leading 18.9 points per game ranks 45th in the nation.
• Houston has a +599 scoring differential, topping opponents by 15.7 points per game. It is putting up 74 points per game, 167th in college basketball, and is allowing 58.3 per outing to rank first in college basketball.
• LJ Cryer is ranked 233rd in college basketball with a team-leading 15.4 points per game.
• The Blue Devils average 35.7 rebounds per game (23rd in college basketball) while conceding 27.1 per contest to their opponents. They outrebound opponents by 8.6 boards per game.
• Flagg's 7.5 rebounds per game lead the Blue Devils and rank 103rd in college basketball play.
• The Cougars win the rebound battle by 6.5 boards on average. They collect 33.1 rebounds per game, 110th in college basketball, while their opponents grab 26.6.
• J'wan Roberts averages 6.3 rebounds per game (260th in college basketball) to lead the Cougars.
• Duke averages 111.3 points per 100 possessions on offense (first in college basketball), and gives up 83.2 points per 100 possessions (sixth in college basketball).
• The Cougars average 102.2 points per 100 possessions on offense (40th in college basketball), and concede 80.5 points per 100 possessions (second in college basketball).

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