Duke vs Houston Basketball Prediction, Odds, Picks, Best Bets for NCAA Tournament Final Four

A Final Four matchup features the No. 1 seed Duke Blue Devils (35-3) and the No. 1 seed Houston Cougars (34-4) playing with a ticket to the national championship game on the line on Saturday at Alamodome. The NCAA Tournament matchup begins at 8:49 p.m. ET, on CBS.

Before you place your bet on this game at FanDuel Sportsbook, here are the NCAA basketball odds and spreads you need to know.

Duke vs. Houston Game Info and Odds

• Game day: Saturday, April 5, 2025
• Game time: 8:49 p.m. ET
• TV channel: CBS
• Location: San Antonio, Texas
• Arena: Alamodome

Duke vs. Houston Picks and Prediction

All college basketball win probability predictions and picks are according to numberFire.
Prediction: Duke win (58%)

Before placing a wager on Saturday's Duke-Houston spread (Duke -4.5) or total (136.5 points), take a look at the betting trends and insights below.

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Duke vs. Houston: ATS Betting Stats and Trends

• Duke is 25-13-0 ATS this season.
• Houston has compiled a 21-16-0 ATS record so far this season.
• The Blue Devils have a worse record against the spread when playing at home (11-6-0) than they do in away games (9-2-0).
• The Cougars have been better against the spread on the road (7-3-0) than at home (10-7-0) this season.

Duke vs. Houston: Moneyline Betting Stats

• Duke has been chosen as the moneyline favorite in 36 games this year and has walked away with the win 33 times (91.7%) in those games.
• This season, the Blue Devils have come away with a win 32 times in 34 chances when named as a favorite of at least -235 or shorter on the moneyline.
• Houston is the moneyline underdog for the first time this season.
• The Cougars have yet to play as a moneyline underdog of +194 or longer.
• Duke has an implied victory probability of 70.1% according to the moneyline set by oddsmakers for this matchup.

Duke vs. Houston Head-to-Head Comparison

• Duke is outscoring opponents by 21.1 points per game with a +801 scoring differential overall. It puts up 83.7 points per game (ninth in college basketball) and allows 62.6 per outing (seventh in college basketball).
• Cooper Flagg ranks 45th in the nation with a team-leading 18.9 points per game.
• Houston is outscoring opponents by 15.7 points per game, with a +599 scoring differential overall. It puts up 74 points per game (167th in college basketball) and gives up 58.3 per contest (first in college basketball).
• LJ Cryer's team-leading 15.4 points per game rank him 233rd in college basketball.
• The Blue Devils rank 23rd in the nation at 35.7 rebounds per game. That's 8.6 more than the 27.1 their opponents average.
• Flagg paces the team with 7.5 rebounds per game (103rd in college basketball play).
• The Cougars prevail in the rebound battle by an average of 6.5 boards. They are grabbing 33.1 rebounds per game (110th in college basketball) compared to their opponents' 26.6.
• J'wan Roberts leads the team with 6.3 rebounds per game (260th in college basketball).
• Duke averages 111.3 points per 100 possessions on offense (first in college basketball), and allows 83.2 points per 100 possessions (sixth in college basketball).
• The Cougars rank 40th in college basketball averaging 102.2 points per 100 possessions on offense, and defensively are second, allowing 80.5 points per 100 possessions.

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