Diamondbacks vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 16

Odds updated as of 6:12 a.m.

MLB action on Tuesday includes the Arizona Diamondbacks facing the San Francisco Giants.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important information regarding this game.

Diamondbacks vs Giants Game Info

• Arizona Diamondbacks (76-75) vs. San Francisco Giants (75-75)
• Date: Tuesday, September 16, 2025
• Time: 9:40 p.m. ET
• Venue: Chase Field -- Phoenix, Arizona
• Coverage: ARID and NBCS-BA

Diamondbacks vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: ARI: (-116) | SF: (-102)
• Spread: ARI: +1.5 (-194) | SF: -1.5 (+160)
• Total: 9 -- Over: (-105) | Under: (-115)

Diamondbacks vs Giants Probable Starting Pitchers

Probable Pitchers: Eduardo Rodríguez (Diamondbacks) - 8-8, 4.98 ERA vs TBA (Giants)

The Diamondbacks will give the ball to Eduardo Rodriguez (8-8), while the Giants' starter has not yet been announced. Rodriguez and his team are 10-15-0 ATS this season when he starts. Rodriguez's team is 7-7 this season when he starts and they are the moneyline favorite.

Diamondbacks vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Diamondbacks win (63.8%)

Diamondbacks vs Giants Moneyline

• San Francisco is a -102 underdog on the moneyline, while Arizona is a -116 favorite at home.

Diamondbacks vs Giants Spread

• The Giants are 1.5-run favorites against the spread for this matchup with the Diamondbacks. The Giants are +160 to cover, while the Diamondbacks are -194 to cover as a 1.5-run underdog on the runline.

Diamondbacks vs Giants Over/Under

• Diamondbacks versus Giants, on Sept. 16, has an over/under of 9, with the over being -105 and the under -115.

Bet on Arizona Diamondbacks vs. San Francisco Giants on FanDuel today!

Diamondbacks vs Giants Betting Trends

• The Diamondbacks have been chosen as favorites in 82 games this year and have walked away with the win 43 times (52.4%) in those games.
• This season Arizona has come away with a win 37 times in 71 chances when named as a favorite of at least -116 on the moneyline.
• The Diamondbacks and their opponents have hit the over in 73 of their 147 games with a total set by oddsmakers this season.
• The Diamondbacks have posted a record of 74-73-0 against the spread this season.
• The Giants have gone 27-32 in games they were listed as the moneyline underdog (winning 45.8% of those games).
• San Francisco has a 22-28 record (winning 44% of its games) when playing as a moneyline underdog of -102 or longer.
• The Giants have played in 149 games with a set over/under, and have combined with their opponents to go over the total 71 times (71-70-8).
• The Giants are 69-80-0 ATS this season.

Diamondbacks Player Leaders

• Geraldo Perdomo has an OPS of .853, fueled by an OBP of .391 to go with a slugging percentage of .462. He has a .290 batting average, as well.
• Among all qualifying hitters in MLB, his batting average ranks 15th, his on-base percentage ranks sixth, and he is 45th in slugging.
• Perdomo will look for his seventh straight game with a hit in this matchup. In his last 10 games he is hitting .400 with a double, a triple, three home runs, eight walks and nine RBIs.
• Corbin Carroll leads Arizona in total hits (135) this season while batting .255 with 76 extra-base hits. He's slugging .542 with an on-base percentage of .337.
• He is 82nd in batting average, 55th in on-base percentage and seventh in slugging among qualifying hitters.
• Carroll brings a two-game streak with at least one hit into this matchup. In his last five games he is hitting .235 with a double, seven walks and two RBIs.
• Ketel Marte has 121 hits this season and has a slash line of .277/.376/.501.
• Gabriel Moreno has nine home runs, 37 RBI and a batting average of .289 this season.

Giants Player Leaders

• Rafael Devers has totaled 143 hits with a .375 on-base percentage, leading the Giants in both categories. He's batting .255 and slugging .476.
• Including all qualified hitters in the big leagues, he is 82nd in batting average, ninth in on-base percentage and 33rd in slugging percentage.
• Jung Hoo Lee is hitting .264 with 30 doubles, 11 triples, eight home runs and 46 walks. He's slugging .409 with an on-base percentage of .328.
• Including all qualified hitters, his batting average places him 49th, his on-base percentage is 76th, and he is 88th in slugging.
• Willy Adames is hitting .230 with 20 doubles, two triples, 28 home runs and 71 walks.
• Matt Chapman is batting .239 with 20 doubles, two triples, 21 home runs and 66 walks.

Diamondbacks vs Giants Head to Head

• 9/15/2025: 8-1 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 9/10/2025: 5-3 ARI (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 9/9/2025: 5-3 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/8/2025: 11-5 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 7/3/2025: 7-2 SF (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/2/2025: 6-5 SF (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 7/1/2025: 8-2 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/30/2025: 4-2 ARI (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 5/14/2025: 8-7 ARI (Favorite: Giants, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/13/2025: 10-6 SF (Favorite: Diamondbacks, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)

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