Diamondbacks vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 15

Odds updated as of 5:17 a.m.

MLB action on Monday includes the Arizona Diamondbacks playing the San Francisco Giants.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Diamondbacks vs Giants Game Info

• Arizona Diamondbacks (75-75) vs. San Francisco Giants (75-74)
• Date: Monday, September 15, 2025
• Time: 9:40 p.m. ET
• Venue: Chase Field -- Phoenix, Arizona
• Coverage: ARID and NBCS-BA

Diamondbacks vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: ARI: (-142) | SF: (+120)
• Spread: ARI: -1.5 (+152) | SF: +1.5 (-184)
• Total: 9.5 -- Over: (-100) | Under: (-122)

Diamondbacks vs Giants Probable Starting Pitchers

Probable Pitchers: Zac Gallen (Diamondbacks) - 11-14, 4.84 ERA vs Kai-Wei Teng (Giants) - 2-4, 7.54 ERA

This contest's pitching matchup is set, as the Diamondbacks will send Zac Gallen (11-14) to the mound, while Kai-Wei Teng (2-4) will take the ball for the Giants. Gallen and his team are 13-17-0 ATS this season when he starts. Gallen's team is 7-10 this season when he starts and they are the moneyline favorite. The Giants have gone 2-3-0 against the spread when Teng starts. The Giants were the moneyline underdog for four Teng starts this season -- they lost each time.

Diamondbacks vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Diamondbacks win (59.8%)

Diamondbacks vs Giants Moneyline

• Arizona is a -142 favorite on the moneyline, while San Francisco is a +120 underdog on the road.

Diamondbacks vs Giants Spread

• The Giants are +1.5 on the spread (-184 to cover), and Arizona is +152 to cover the runline.

Diamondbacks vs Giants Over/Under

• A combined run total of 9.5 has been set for Diamondbacks-Giants on Sept. 15, with the over at -100 and the under at -122.

Bet on Arizona Diamondbacks vs. San Francisco Giants on FanDuel today!

Diamondbacks vs Giants Betting Trends

• The Diamondbacks have been chosen as favorites in 81 games this year and have walked away with the win 42 times (51.9%) in those games.
• This season Arizona has come away with a win 21 times in 40 chances when named as a favorite of at least -142 on the moneyline.
• The Diamondbacks and their opponents have gone over in 73 of their 146 games with a total set by sportsbooks this season.
• The Diamondbacks have an against the spread record of 73-73-0 in 146 games with a line this season.
• The Giants have won 46.6% of the games this season they were the underdog on the moneyline (27-31).
• San Francisco has gone 11-12 in games it has played as a moneyline underdog with odds of +120 or longer (47.8%).
• The Giants have had an over/under set by bookmakers 148 times, and have combined with opponents to go over the total in 71 of those games (71-70-7).
• The Giants have a 69-79-0 record ATS this season (covering 46.6% of the time).

Diamondbacks Player Leaders

• Geraldo Perdomo leads Arizona OPS (.840) this season. He has a .286 batting average, an on-base percentage of .387, and a slugging percentage of .454.
• Among qualifying hitters, he is 15th in batting average, his on-base percentage ranks sixth, and he is 53rd in slugging.
• Perdomo hopes to build on a five-game hitting streak in this matchup. During his last five outings he is hitting .438 with two home runs, five walks and four RBIs.
• Corbin Carroll has 134 hits, which leads Arizona batters this season. He's batting .255 with 75 extra-base hits. He's also slugging .542 with an on-base percentage of .337.
• Among qualified batters, he ranks 84th in batting average, 55th in on-base percentage and eighth in slugging percentage.
• Ketel Marte has collected 121 base hits, an OBP of .377 and a slugging percentage of .506 this season.
• Marte enters this game with two games in a row with at least one hit. During his last five outings he is batting .217 with a double and an RBI.
• Gabriel Moreno is batting .292 with a .349 OBP and 37 RBI for Arizona this season.
• Moreno takes a five-game hitting streak into this game. In his last five games he is hitting .500 with a double, two home runs, three walks and six RBIs.

Giants Player Leaders

• Rafael Devers has accumulated an on-base percentage of .377 and has 143 hits, both team-high numbers for the Giants. He's batting .257 and slugging .479.
• Including all qualified hitters in the big leagues, he is 80th in batting average, eighth in on-base percentage and 29th in slugging percentage.
• Jung Hoo Lee is hitting .266 with 30 doubles, 11 triples, eight home runs and 45 walks. He's slugging .411 with an on-base percentage of .329.
• Including all qualified hitters, he ranks 45th in batting average, 74th in on-base percentage and 87th in slugging percentage.
• Willy Adames is hitting .232 with 20 doubles, two triples, 28 home runs and 71 walks.
• Matt Chapman has 20 doubles, two triples, 21 home runs and 65 walks while batting .241.

Diamondbacks vs Giants Head to Head

• 9/10/2025: 5-3 ARI (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 9/9/2025: 5-3 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/8/2025: 11-5 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 7/3/2025: 7-2 SF (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/2/2025: 6-5 SF (Favorite: Diamondbacks, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 7/1/2025: 8-2 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 6/30/2025: 4-2 ARI (Favorite: Giants, Spread: -1.5, Total: 8.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 5/14/2025: 8-7 ARI (Favorite: Giants, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/13/2025: 10-6 SF (Favorite: Diamondbacks, Spread: -1.5, Total: 7.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 5/12/2025: 2-1 ARI (Favorite: Diamondbacks, Spread: -1.5, Total: 8, Favorite Moneyline: -118, Underdog Moneyline: -100)

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